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2型糖尿病肾病患者血清内脂素水平的变化及其与氧化应激的关系 被引量:7

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摘要 目的观察2型糖尿病肾病(T2DN)患者血清内脂素水平的变化及其与氧化应激的关系。方法分别测定30例正常对照组(NC组)、单纯2型糖尿病(T2DM组)、T2DN组患者血清内脂素、丙二醛(MDA)、超氧化物歧化酶(SOD)和过氧化氢酶(CAT)的水平。结果 T2DM组血清内脂素和MDA明显高于NC组(均P<0.01),T2DN组血清内脂素和MDA明显高于T2DM组(均P<0.01)。T2DN组血清SOD和CAT明显低于T2DM组(P<0.01),T2DN患者血清内脂素与体质指数(BMI)、空腹血糖(FPG)、糖化血红蛋白(Hb A1c)、HOMA-IR、甘油三酯(TG)和MDA呈明显正相关(r=0.418,r=0.475,r=0.359,r=0.427,r=0.518,r=0.522,均P<0.01),与SOD和CAT呈明显负相关(r=-0.583,r=-0.469,均P<0.01)。结论T2DN患者血清内脂素水平升高,同时存在氧化应激,内脂素与氧化应激相互作用和相互影响,共同参与T2DN的发生发展。
出处 《中国老年学杂志》 CAS 北大核心 2017年第8期1902-1903,共2页 Chinese Journal of Gerontology
基金 武汉市卫生计生委2013年度临床医学科研立项(No.WX13C10)
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