摘要
目的:探讨双胎孕妇孕晚期血脂水平与妊娠期并发症及不良妊娠结局的相关因素。方法:回顾性分析2017年11月至2019年11月于本院产科分娩的138例双胎孕妇(双胎组)及同期150例单胎孕妇(单胎组)的孕晚期临床资料,同时双胎孕妇按血脂水平分为血脂异常组(94例)及血脂正常组(44例),比较组间血脂水平、妊娠期并发症及不良妊娠结局的发生情况。双胎孕晚期血脂水平与妊娠期并发症及不良妊娠结局之间进行Spearman相关性分析和Logistic回归模型分析。结果:(1)双胎组甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白(LDL-C)、载脂蛋白B(Apo-B)水平明显高于单胎组,高密度脂蛋白(HDL-C)、载脂蛋白AI(Apo-AI)水平明显低于单胎组,差异均有统计学意义(P<0.05)。(2)双胎组孕妇妊娠期并发症及不良妊娠结局的发生率显著高于单胎组,差异有统计学意义(P<0.05);双胎血脂异常组孕妇妊娠期并发症及不良妊娠结局的发生率显著高于血脂正常组,差异有统计学意义(P<0.05)。(3)双胎孕晚期TG、Apo-B为妊娠期糖尿病的独立危险因素(OR>1,P<0.05);TG为妊娠期高血压疾病、剖宫产的独立危险因素(OR>1,P<0.05);HDL-C为妊娠期肝内胆汁淤积症、剖宫产的保护性因素(OR<1,P<0.05);TC为早产、胎儿窘迫的独立危险因素(OR>1,P<0.05),LDL-C为早产、胎儿窘迫的保护性因素(OR<1,P<0.04)。结论:双胎孕妇孕晚期血脂水平、妊娠期并发症及不良妊娠结局的发生率显著高于单胎孕妇,双胎血脂异常孕妇妊娠期并发症及不良妊娠结局的发生率显著高于血脂正常孕妇,双胎孕妇孕晚期升高的血脂与不良妊娠结局之间具有相关性,应早期积极干预双胎孕妇的血脂,降低不良妊娠结局的发生。
Objective:To investigate the relationship between lipid levels and pregnant complications and adverse pregnancy outcomes in late twin pregnancy.Methods:The clinical data of 138 twin pregnancies and 150 single pregnancies delivered in our hospital from November 2017 to November 2019 were analyzed retrospectively.Twin pregnancies were divided into dyslipidemia(94 cases) and normal(44 cases) groups according to blood lipid levels, and the incidences of adverse pregnancy outcomes were compared between groups.Results:(1)The levels of triglyceride(TG),cholesterol(TC),low density lipoprotein cholesterol(LDL-C),apolipoprotein B(Apo-B)in twin group were significantly higher than those in singleton group, and the levels of high density lipoprotein cholesterol(HDL-C),apolipoprotein AI(Apo-AI)were significantly lower than those in singleton group(P<0.05).(2)The incidence of pregnant complications and adverse pregnancy outcomes in dyslipidemia group was significantly higher than normal group(P<0.05).(3)TG and apo-B were risk factors of gestational diabetes mellitus(OR>1,P<0.05);TG was a risk factor of gestational hypertension and cesarean section(OR>1,P<0.05).HDL-C was a protective factor of cholestasis of pregnancy and cesarean section(OR<1,P<0.05);TC was a risk factor of premature delivery and fetal distress(OR>1,P<0.05),while LDL-C was a protective factor(OR<1,P<0.05).Conclusions:There was a correlation between increased blood lipid in late twin pregnancy and pregnant complications and adverse pregnancy outcome.
作者
古丽尼格尔·木合台尔
热洋尼沙·卡的
阿布力克木·吐尔地
GU Linigeer MU Hetaier;RE Yangnisha KADe;A Bulikimu TUErdi(Department of Endocrinology,The First Affiliated Hospital of Xinjiang Medical University,Urumqi Xinjiang 830000,China;Department of Comprehensive Internal Medicine,The First Affiliated Hospital of Xinjiang Medical University,Urumqi Xinjiang 830000,China)
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2021年第9期705-709,共5页
Journal of Practical Obstetrics and Gynecology
关键词
双胎
妊娠晚期
血脂
妊娠结局
Twins
Late pregnancy
Blood lipid level
Pregnancy outcome
