摘要
目的探讨熊去氧胆酸胶囊治疗胆汁酸正常的妊娠期肝内胆汁淤积症(ICP)患者的疗效及对妊娠结局的影响。方法选取该院2013年7月-2015年7月收治的80例胆汁酸正常的ICP患者进行回顾性分析,其中40例患者给予熊去氧胆酸胶囊治疗的患者作为观察组,40例患者未给予熊去氧胆酸胶囊治疗的患者作为对照组,观察两组患者的瘙痒评分、瘙痒症状、肝功能指标丙氨酸转氨酶(ALT)、谷草转氨酶(AST)、总胆汁酸(TBA)、总胆红素(TBIL)、直接胆红素(DBIL)的变化及妊娠结局。结果观察组患者的瘙痒评分明显少于对照组,差异具有统计学意义(P<0.05);治疗后观察组患者ALT、AST、TBIL、DBIL水平与对照组存在统计学差异(P<0.05);观察组的剖宫产率、产后出血率、胎儿宫内窘迫率、新生儿窒息率明显少于对照组,差异具有统计学意义(P<0.05),而观察组的新生儿体质量和新生儿Apgar评分均高于对照组,差异具有统计学意义(P<0.05);随访1周,观察组的TBA水平没有变化,为(3.55±0.57)μmol/L,对照组的TBA水平为(39.5±10.5)μmol/L,两组之间存在统计学差异(P<0.05);而且观察组的瘙痒症状缓解,对照组瘙痒症状未改善或有加剧。结论熊去氧胆酸胶囊应用于胆汁酸正常的ICP患者的治疗,能有效改善患者的瘙痒症状,减少不良妊娠的发生,新生儿预后比较好。
Objective To explore the curative effect of ursodeoxycholic acid in treatment of intrahepatic cholestasis of pregnancy（ ICP）in patients with normal bile acid and the effect on pregnancy outcome. Methods Eighty ICP patients with normal bile acid treated in the hospital from July 2013 to July 2015 were analyzed retrospectively,then they were divided into two groups,the patients in observation group were treated by ursodeoxycholic acid capsules,while the patients in control group were not treated by ursodeoxycholic acid capules. The scores and symptoms of pruritus,the changes of liver function indexes [alanine aminotransferase（ ALT）,glutamic oxalacetic transaminase（ AST）,total bile acid（ TBA）,total bilirubin（ TBIL）,direct bilirubin（ DBIL） ],and pregnancy outcomes in the two groups were observed. Results The score of pruritus in observation group was statistically significantly less than that in control group（ P〈0. 05）. There were statistically significant differences in the levels of ALT,AST,TBIL,and DBIL after treatment between the two groups（ P〈0. 05）.The rate of cesarean section,the incidence rates of postpartum hemorrhage,fetal intrauterine distress,and neonatal asphyxia in observation group were statistically significantly lower than those in control group（ P〈0. 05）. Neonatal weight and neonatal Apgar score in observation group were statistically significantly higher than those in control group（ P〈0. 05）. After follow-up for one week,TBA level in observation group didn＇t change significantly,which was（ 3. 55±0. 57） μmol/L,TBA level in control group was（ 39. 5±10. 5） μmol/L,there was statistically significant difference between the two groups（ P〈0. 05）. The symptoms of pruritus in observation group were relieved,while the symptoms of pruritus in control group were not relieved,or even worse. Conclusion Ursodeoxycholic acid capules can treat ICP patients with normal bile acid,which can effectively improve the symptoms of pruritus and reduce the o
出处
《中国妇幼保健》
CAS
2017年第8期1646-1648,共3页
Maternal and Child Health Care of China
关键词
熊去氧胆酸胶囊
胆汁酸
妊娠期肝内胆汁淤积症
妊娠结局
Ursodeoxycholic acid capsule
Bile acid
Intrahepatic cholestasis of pregnancy
Pregnancy outcome
