摘要
目的探讨思美泰联合熊去氧胆酸治疗ICP的疗效及针对不同妊娠期ICP的疗效区别。方法收集该院2013年6月-2014年12月收治ICP患者80例,按照ICP分级随机分为A组、B组和C组。A组采用思美泰治疗,B组采用熊去氧胆酸治疗,C组采用联合用药,比较3组患者实验室指标、瘙痒评分和妊娠结局,并比较C组在治疗妊娠中期和妊娠晚期患者的实验室指标和瘙痒评分的不同。结果 13组治疗前TBA和肝功能、瘙痒指数无明显差异,治疗后A组和B组这些指标和指数无明显差异,C组指标和指数改善优于A组和B组,差异具有统计学意义;23组在剖宫产、胎儿窘迫和羊水污染以及Apgar≤7分发生无明显差异,C组在产后出血量、孕周和新生儿体重方面优于A组和B组,差异明显;3C组妊娠中期和妊娠晚期患者治疗前TBA、TBIL、ALT、AST、瘙痒指数比较无明显差异;治疗后妊娠中期TBA、TBIL、ALT、AST、瘙痒指数方面优于妊娠晚期,比较具有统计学意义(P<0.05)。结论思美泰联合熊去氧胆酸治疗ICP对减低血清中的胆汁酸和减少及改善肝功能及延长孕周、增加新生儿体重有重要作用,且对妊娠中期患者的疗效更显著。
Objective To explore the curative effect of transmetil combined with ursodesoxycholic acid in treatment of intrahepatic cholestasis of pregnancy（ ICP） and the difference of curative effects during different periods. Methods Eighty ICP patients treated in the hospital from June 2013 to December 2014 were collected and randomly divided into group A,group B,and group C according to the grade of ICP. The patients in group A were treated with transmetil,the patients in group B were treated with ursodesoxycholic acid,the patients in group C were treated with transmetil combined with ursodesoxycholic acid. The laboratory indexes,pruritus scores,and pregnancy outcomes in the three groups were compared. The laboratory indexes and pruritus scores during middle pregnancy and late pregnancy in group C were compared. Results Before treatment,there was no statistically significant difference in TBA,liver function,and pruritus index among the three groups. After treatment,there was no statistically significant difference in TBA,liver function,and pruritus index between group A and group B,but TBA,liver function,and pruritus index in group C were better than those in group A and group B,there were statistically significant differences. There was no statistically significant difference in cesarean section,fetal distress,amniotic fluid contamination,and Apgar score≤7 among the three groups. The amount of postpartum hemorrhage,gestational age,and neonatal birth weight in group C were significantly better than those in group A and group B. There was no statistically significant difference in TBA,TBIL,ALT,AST,and pruritus index before treatment between middle pregnancy and late pregnancy in group C,after treatment,TBA,TBIL,ALT,AST,and pruritus index during middle pregnancy were statistically significantly better than those during late pregnancy（ P〈0.05）. Conclusion Transmetil combined with ursodesoxycholic acid in treatment of ICP can reduce serum bile acid,improve liver function,prolong gestational week,and increase neon
出处
《中国妇幼保健》
CAS
2016年第6期1297-1300,共4页
Maternal and Child Health Care of China
基金
浙江省台州市科研项目(1301ky14)
关键词
思美泰
熊去氧胆酸
妊娠期肝内胆汁淤积症
妊娠不同时期
Transmetil
Ursodeoxycholic acid
Intrahepatic cholestasis of pregnancy
Pregnancy during different period
