摘要
Objective To evaluate the clinical efficacy of acupuncture in treatment of postpartum depression. Methods Pubmed database and Embase database were retrieved online in English, and China National Knowledge Internet （CNKI）, China Biology Medicine disc （CBM）, VIP database and Wanfang Data were retrieved in Chinese. Literature in recent 10 years relating to clinical randomized controlled trials of acupuncture in treatment of postpartum depression were collected, and Meta analysis was performed by adopting RevMan5.3. Results Fourteen articles were included in the study in total; it was shown from HAMD result that after combination, WMD=-2.27, 95%CI （-2.55, 0.01）; according to Z-test, Z=2.95, P=0.05, and the difference in efficacy between treatment group and control group was statistically significant. It was shown from EPDS result that after combination, WMD=-0.53, 95%CI （-0.92, -0.03）; according to Z-test, Z=2.08, P〈0.05, and the difference in efficacy between treatment group and control group was statistically significant. During the analysis taking estradiol as standard, it was shown from the result that after combination, WMD=63.99, 95%CI （13.39, 114.60）; according to Z-test, Z=2.48, P〈0.05, and the difference in efficacy between treatment group and control group had remarkably statistical significance. During the analysis taking effective rate as standard, it was shown from the result that after combination, OR=3.15, 95%CI （2.19, 4.55）; according to Z-test, Z=6.14, P〈0.05, and the difference in efficacy between treatment group and control group had remarkably statistical significance. Conclusion Acupuncture treatment for postpartum depression is effective, but more clinical randomized controlled trials with high quality and large sample size are still needed to verify the result.
目的:评价针刺治疗产后抑郁症的临床疗效。方法:在线英文检索Pubmed数据库、Embase数据库,中文检索中国知网(CNKI)数据库、中国生物医学(CBM)数据库、维普(VIP)数据库、万方数据库,搜集近10年来关于针刺治疗产后抑郁症的临床随机对照试验类相关文献,采用Rev Man 5.3进行Meta分析。结果:共纳入文献14篇,HAMD结果示合并后WMD=-1.27,95%CI(-2.55,0.01),经Z检验,Z=1.95,P=0.05,治疗组和对照组疗效差异有统计学意义。EPDS结果示合并后WMD=-0.53,95%CI(-0.92,-0.03),经Z检验,Z=2.08,P<0.05,治疗组和对照组疗效差异有统计学意义。利用雌二醇为标准的分析中,结果示合并后WMD=63.99,95%CI(13.39,114.60),经Z检验,Z=2.48,P﹤0.05,治疗组与对照组疗效差异有统计学意义。利用有效率为标准的分析中,结果示合并后OR=3.15,95%CI(2.19,4.55),经Z检验,Z=6.14,P﹤0.05,治疗组与对照组疗效差异有统计学意义。结论:针刺治疗产后抑郁症有效,但仍需要更多高质量大样本的临床随机对照试验来进行验证。
