摘要
目的观察泰山磐石散加减治疗复发性流产患者临床疗效。方法随机将复发性流产患者60例分为黄体酮治疗组(HTT组)和泰山磐石散联合黄体酮治疗组(TSPS组),同时选取30例正常妊娠患者为空白对照组(ZC组)。ZC组不给予任何措施;HTT组给予黄体酮注射液肌肉注射,15mg/次,3次/周;TSPS组给予黄体酮注射的同时给予泰山磐石散口服,1剂/d,共治疗12周。分别于患者治疗0、2、4、6、8、10、12周检测血清人体绒膜促性腺激素(HCG)、孕酮含量,于治疗12周结束后,对各组患者进行疗效评价,并跟踪至患者妊娠结束,计算各组患者妊娠分娩率。结果治疗前,HTT组和TSPS组患者血清HCG、孕酮水平明显低于ZC组,经治疗后,水平均有不同程度上升(P<0.05),以TSPS组效果较为明显(P<0.05);计算各组有效率(分娩率),ZC组为93.3%,HTT组为70%,TSPS组为86.7%,TSPS组明显优于HTT组(P<0.05)。结论泰山磐石散能有效改善复发性流产患者妊娠早起血清HCG、孕酮水平,治疗效果优于单纯应用黄体酮治疗。
Objective To observe the clinical therapeutic effects of the modified taishan panshi san on recurrent spontaneous abortion. Methods Sixty patients of recurrent spontaneous abortion were divided into a progesterone group and a combined medication group of taishan panshi san and progesterone group （combined medicine group）. Additionally ,30 patients of normal pregnancy were selected in a normal group. In the normal group, no any measure was given. In the progesterone group, the progesterone injection was giv- en for muscular injection, 15rag each time, three times a week. In the combined medicine group, the progester- one injection and the oral administration of taishan panshi san were applied in combination, one dose a day, for 12 weeks totally. Separately,in 0,2,4,6,8,10 and 12 weeks of treatment, HCG and progesterone were de- tected. At the end of 12 weeks ,the clinical therapeutic effects were evaluated and traced till the end of preg- nancy. The delivery rate was calculated in each group. Results Before treatment, in the progesterone group and the combined medicine group, the levels of HCG and progesterone were lower apparently than those in the normal group. After treatment, the levels were increased to different degrees （ P 〈 0.05 ）, of which, the results in the combined medicine group were more obvious （P 〈 0.05 ）. The effective rate （ delivery rate） was 93.3 % in the normal group,was 70% in the progesterone group and was 86.7% in the combined medicine group. The result in the combined medicine group was better apparently than that in the progesterone group （ P 〈 0.05 ）. Conclusion Taishan panshi san effectively increases the levels of serum HCG and progesterone at the early stage of pregnancy in the patients of recurrent spontaneous abortion and the therapeutic effects are better than those with simple treatment of progesterone.
出处
《世界中西医结合杂志》
2017年第3期369-371,共3页
World Journal of Integrated Traditional and Western Medicine
基金
沈阳市科技创新专线资金-应用基础研究专项(F14-231-1-15)
