摘要
建立了电感耦合等离子体质谱(ICP-MS)法同时检测磷酸特地唑胺中的5种微量金属元素。以硝酸为消解剂,采用微波消解法进行前处理,在线加入内标消除基体效应,运用碰撞反应池技术消除多原子分子干扰。结果 5种金属元素平均回收率为83.6%~113.0%(n=9),检测限为1~20?g/kg。微波消解-ICP-MS法样品用量少、方法灵敏度高、分析速度快,能同时分析磷酸特地唑胺中的5种微量金属元素。
An inductively coupled plasma mass spectrometry （ICP-MS） method was established for the determination of 5 metal elements in tedizolid phosphate. The samples were digested by nitric acid with microwave. The matrix and spectra interference of the ICP-MS were eliminated by online internal standard addition and collision cell.Their average recoveries were in the range of 83.6%—113.0%（n=9）. Their limits of detection were 1—20 μg/kg. The microwave digestion-ICP-MS method is highly sensitive with a fast analysis rate, and it only requires a small amount of sample, which can simultaneously analyze various elements in tedizolid phosphate.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2017年第4期549-552,共4页
Chinese Journal of Pharmaceuticals
关键词
磷酸特地唑胺
微波消解
金属元素
电感耦合等离子体质谱
含量测定
tedizolid phosphate
microwave digestion
metal element
inductively coupled plasma mass spectrometry （ICP-MS）
content determination
