摘要
目的比较耐多药肺结核采用含左氧氟沙星或莫西沙星方案的疗效。方法选择深圳市慢性病防治中心接诊的耐多药肺结核患者70例,按随机数字表法分为对照组与研究组,各35例。对照组患者采用含左氧氟沙星方案治疗,研究组患者采取含莫西沙星方案治疗,观察并记录两组患者的症状改善时间、临床疗效、不良反应,以及治疗2,4,8,12个月时的痰菌阴转率。结果研究组患者症状改善时间明显短于对照组患者(P<0.05);研究组患者治疗2,4,8个月时的痰菌阴转率明显高于对照组患者(P<0.05);两组患者病灶吸收率、空洞闭合率、不良反应发生率比较,差异无统计学意义(P>0.05)。结论含莫西沙星方案治疗耐多药肺结核效果优于含左氧氟沙星方案,临床可优先参考使用。
Objective To explore the therapeutic effect of levofloxacin or moxifloxacin-containing regimens in patients with multi-drug resistant pulmonary tuberculosis. Methods 70 patients with multi-drug resistant pulmonary tuberculosis admitted in Shenzhen Center for Chronic Disease Prevention and Control were selected and randomized into two groups,35 cases in each group. The control group was treated with levofloxacin regimen,and the study group was treated with moxifloxacin regimen. The time of symptom improvement,clinical effect,adverse reaction,and the rate of sputum negative conversion at 2,4,8 and 12 months of treatment were compared. Results The time of symptom improvement was significantly shorter in study group than that in control group（P 〈 0. 05）. The rate of sputum negative conversion in treatment group was significantly higher than that in control group at 2,4,8 and 12 months of treatment （P 〈 0. 05）. There was no significant difference between the two groups in the absorption rate of the lesion,the rate of occlusion and the incidence of adverse reactions（P 〉 0. 05）. There is no significant difference in the absorption rate of the lesion,the rate of occlusion and the incidence of adverse reactions. Conclusion Moxifloxacin-containing regimen is more effective than levofloxacin in the treatment of multi-drugresistant pulmonary tuberculosis.
出处
《中国药业》
CAS
2017年第4期59-61,共3页
China Pharmaceuticals
关键词
耐多药肺结核
左氧氟沙星
莫西沙星
疗效
multi-drug resistant pulmonary tuberculosis
levofloxacin
moxifloxacin
effect
