摘要
目的观察左氧氟沙星、多西环素和奥美拉唑治疗幽门螺杆菌(HP)感染消化性溃疡的效果。方法选取医院收治的HP感染消化性溃疡患者136例,按治疗方法不同分为研究组和对照组,各68例。对照组患者采取阿莫西林+甲硝唑+雷贝拉唑治疗,研究组患者联合使用左氧氟沙星200 mg+多西环素100 mg+奥美拉唑20 mg治疗,治疗4周后,分析治疗效果、HP根除率和不良反应发生情况。结果研究组患者治疗总有效率94.12%,显著高于对照组的72.06%(P<0.05);研究组HP根除率为88.24%,显著高于对照组的73.53%(P<0.05);两组患者在治疗中均未出现严重不良反应,不良反应主要为胃肠道反应,研究组患者不良反应发生率为4.41%,显著低于对照组的17.65%(P<0.05)。结论采用左氧氟沙星、多西环素和奥美拉唑治疗HP感染消化性溃疡能提高治疗效果,且不良反应小,安全有效,值得临床推广。
Objective To analyze and discuss the efficacy of levofloxacin, omeprazole and doxycycline in treating Helicobacter pylori in- fection- associated peptic ulcer. Methods 136 patients with Helicobacter pylori infection associated peptic ulcer in the hospital were selected and divided into control group（68 cases） and study group（68 cases） according to different treatment. The control group was given treatment of amoxicillin ＋ metronidazole ＋ rabeprazole, and the study group was given treatment of levofloxacin 200 mg ＋ doxycycline 100 mg＋ omeprazole 20 mg. The clinical efficacy, Hp eradication rate and adverse reactions of the two groups were compared after 4 weeks of treatment. Results The total effectiv~ rate of the study group was 94.12%, which was significantly higher than 72.06% ofthe control group（ P 〈 0. 05）; the Hp eradication rate of the study group was 88.24%, which was significantly higher than 73.53% of the control group（ P 〈 0.05 ）;the two groups had no severe adverse reactions during the treatment, and the main adverse reactions were gastrointestinal reactions, the incident rate of adverse reactions in the study group was 4.41%, which was significantly lower than 17.65% of the the control group（ P 〈 0. 05）. Conclusion The triple therapy of levofloxacin combined with omeprazole and doxycycline in treating Helicobacter pylori infection- associated peptic ulcer can effectively improve the treatment effect and reduce the incidence rate of adverse reactions, which is worthy of clinical promotion.
出处
《中国药业》
CAS
2016年第3期113-115,共3页
China Pharmaceuticals
