摘要
目的探讨瑞舒伐他汀对急性目发性脑出血(ASICH)患者脂质过氧化损伤的保护作用。方法将纳入研究的74例ASICH患者随机分为研究组和对照组各37例。两组患者均予以控制颅内压、血压和血糖、止血等对症支持治疗。研究组患者加用口服瑞舒伐他汀10 mg,1次/d、连用8周。观察并记录两组治疗前后血脂、血清SOD和MDA指标的变化情况,并评估其临床疗效及不良反应。结果治疔8周后.研究组LDL-C、TC、TG指标较前明显下降,HDL-C指标较前明显上升(P<0.05),而对照组LDL-C、H DL-C、TC、TG治疔前后无明显变化(P>0.05);两组血清SOD水平较前明显上升,MDA水平较前明显下降(P<0.05或P<0.01),且研究组变化幅度较对照组更明显(P<0.05);研究组临床总有效率(94.59%)明显高于对照组(78.38%)(χ~2=4.16、P<0.05);两组治疗中出现不良反应8例,其中对照组3例,研究组5例,两组比较差异不明显(χ~2=0.14,P>0.05)。结论 AS1CH予以瑞舒伐他汀治疗的疗效较显著,安全性较好,其作用机制可能与其升高血清SOD水平、降低血清MDA水平、对脑出血引起的脂质过氧化损伤具有保护作用密切相关。
Objective To discuss the protection effect of rosuvastatin on lipid peroxidation damage of patients with acute spontaneous intracerebral hemorrhage. Methods A total of 74 cases of patients with acute spontaneous intracere- bral hemorrhage were divided into research group and control group, with 37 cases in each group. The patients in two groups were given symptomatic and supporting treatment, such like control of intracranial pressure, blood pressure and blood sugar, hemostasis and etc. The patients in research group were additionally given 10 mg oral rosuvastatin, once a day for 8 weeks. The changes of blood fat, serum SOD and MDA levels of patients in two groups before and after medi- cal treatment were observed and recorded, and the clinical curative effect and untoward effect were evaluated as well. Results After 8 weeks＇medical treatment, LDL-C, TC and TG in research group were obviously declined than before, while HDL-C was obviously rose than before（P〈0.05）, and the LDL-C, HDL-C, TC and TG in control group showed no obvious changes before and after treatment （P〉0.05）. Serum SOD levels of patients in two groups were obviously rose than before, while MDA levels were obviously declined than before（P〈0.05 or P〈0.01）, and the changing rate of patients in research group was much higher than those in control group （P〈0.05）. Total clinical efficiency of patients in research group （94.59%） was much higher than that in control group （78.38%） （X2=4.16, P〈0.05）. 8 cases of untoward effect were appeared on patients in two groups during the medical treatment, with 3 and 5 cases of patients in control group and research group respectively, and＇ after comparing the occurrence rates of untoward effect of patients in two groups, no statistical differences were appeared（x2=0.14, P〉0.05）. Conclusion Rosuvastatin has significant curative effect on acute spontaneous intracerebral hemorrhage, with high security, whose mechanism of action may have close effect on reducing blood fa
出处
《中国现代医生》
2017年第5期29-32,共4页
China Modern Doctor
关键词
急性自发性脑出血
瑞舒伐他汀
血脂
超氧化物歧化酶
丙二醛
Acute spontaneous intracerebral hemorrhage
Rosuvastatin
Blood fat
Superoxide dismutase（SOD）
Malondialdehyde（M DA）
