摘要
目的依达拉奉+尼莫地平治疗高血压脑出血的临床分析。方法将68例高血压脑出血患者作为临床研究对象,均为2017年7月至2018年6月在我院治疗的患者。将所有研究对象按照盲选方法分为对照组34例和观察组34例两组。对照组患者给予吸氧、降低头部温度、静脉滴注甘露醇降颅压以及保护脑神经元等常规治疗,在此基础上观察组患者加用依达拉奉+尼莫地平治疗。治疗1个月后,观察两组患者的血肿体积、水肿体积、血浆内皮素(ET-1)水平以及神经功能缺损症状改善情况,并评估临床治疗效果。结果治疗前两组患者的血肿体积、水肿体积、NIHSS评分以及血浆ET-1水平相比较无统计学意义(P>0.05)。治疗1个月后,对照组和观察组患者的血肿体积及水肿体积比治疗前均明显减小,其NIHSS评分均明显降低,血浆ET-1水平明显下降;且观察组患者的血肿体积、水肿体积、血浆ET-1水平以及NIHSS指标与对照组相比改善更加明显,差异具有统计学意义(P<0.05)。观察组患者的治疗有效率为97.06%,明显高于对照组的治疗有效率79.42%,组间差异具有统计学意义(P<0.05)。结论高血压脑出血患者采用依达拉奉+尼莫地平治疗疗效可靠,能够显著减轻血肿及水肿症状,从而促进患者的神经功能恢复。
Objective To study the clinical effect of edaravone plus nimodipine in the treatment of hypertensive intracerebral hemorrhage.Methods Sixty-eight patients with hypertensive intracerebral hemorrhage were treated in our hospital from July 2017 to June 2018.All the subjects were divided into control group(34 cases)and observation group(34 cases)according to the blind selection method.The patients in the control group were given routine treatment such as oxygen inhalation,head temperature reduction,intravenous mannitol to reduce intracranial pressure and neuron protection.On this basis,the patients in the observation group were treated with edaravone plus nimodipine.One month after treatment,the hematoma volume,edema volume,plasma endothelin-1(ET-1)level and neurological deficit symptoms of the two groups were observed,and the clinical therapeutic effect was evaluated.Results There was no significant difference in hematoma volume,edema volume,NIHSS score and plasma ET-1 level between the two groups before treatment(P>0.05).One month after treatment,the hematoma volume and edema volume of the patients in the control group and the observation group were significantly reduced compared with those before treatment,their NIHSS scores were significantly reduced,and the plasma ET-1 level was significantly decreased.The hematoma volume,edema volume,plasma ET-1 level and NIHSS index of the patients in the observation group were significantly improved compared with those in the control group,with statistical significance(P<0.05).The effective rate of treatment in the observation group was 97.06%,which was significantly higher than that in the control group(79.42%).There was a significant difference between the two groups(P<0.05).Conclusion Edaravone plus nimodipine is effective in the treatment of hypertensive intracerebral hemorrhage.It can significantly relieve the symptoms of hematoma and edema,and promote the recovery of neurological function.
作者
侯晓磊
孙传传
张海宁
HOU Xiaolei;SUN Chuanchuan;ZHANG Haining(Department of Pharmacy,Zaozhuang Municipal Hospital,Zaozhuang 277101,China)
出处
《中国医药指南》
2021年第11期22-24,共3页
Guide of China Medicine
关键词
高血压脑出血
依达拉奉
尼莫地平
临床疗效
Hypertensive cerebral hemorrhage
Edaravone
Nimodipine
Clinical efficacy
