摘要
目的探讨伊曲康唑在慢阻肺合并真菌感染治疗的疗效。方法选取近期来我科住院治疗的慢阻肺合并真菌感染的患者并随机分为两组,每组各100例,其中对照组常规治疗的基础上加用氟康唑,观察组在在常规治疗的基础上采用氟康唑针+伊曲康唑胶囊序贯治疗,观察两组患者在用药后的基本疗效及不良反应情况。结果两组患者合并真菌感染分别为:白假丝酵母菌、曲霉菌、未分类真菌、混合感染,而两组患者之间疗效比较,P<0.05,差异有统计学意义。对照组患者出现29例不良反应,观察组出现27例不良反应,两组之间不良反应的比较无明显差异,P>0.05。结论伊曲康唑对于慢阻肺合并真菌感染的患者,疗效确切,优于氟康唑,且使用安全。
Objective To investigate the curative effect of itraconazole in treatment of COPD patients com- plicated with fungal infection. Methods 200 COPD patients complicated with fungal infection were randomly divid- ed into two groups, 100 cases in each group. On the basis of conventional therapy, the control group was given flu- conazole, and the observation group was given fluconazole and itraconazole capsules sequential treatment. Their cura- tive effect and adverse reactions were observed and compared between the two groups. Results The fungal infection mainly included Candida albieans, Aspergillus, fungal unsorted, and mixed infection. The curative efficacy showed significant difference between the two groups （ P 〈 0. 05 ）. The control group had 29 cases of adverse reactions, and the observation group had 27 cases of adverse reactions （ P 〉 0.05 ）. Conclusion The curative effect of itraconazole is superior to fluconazole, with high safety for COPD patients complicated with fungal infection.
出处
《临床肺科杂志》
2017年第5期868-870,共3页
Journal of Clinical Pulmonary Medicine
关键词
慢性阻塞性肺疾病
真菌感染
伊曲康唑
疗效
chronic obstructive pulmonary disease
fungal infection
itraconazole
efficacy
