摘要
目的:探究 ICU 慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者并发真菌感染的危险因素及探讨防治策略。方法:回顾性分析 2018 年 3 月 -2019 年 3 月本院 ICU 收治的 217 例COPD 患者的临床资料,按照是否并发真菌感染分为真菌感染组(n=48)和未并发真菌感染组(n=169) 。分析 ICU COPD 患者并发真菌感染的独立危险因素。结果:两组性别、年龄、BMI、COPD 分级及是否合并高血压及右心衰竭比较,差异均无统计学意义(P>0.05);两组是否合并高血糖、抗菌药物使用时间及是否合并使用糖皮质激素比较,差异均有统计学意义(P<0.05) 。合并糖尿病、抗菌药物使用时间≥10 d 及合并使用糖皮质激素为 ICU COPD 患者并发真菌感染的独立危险因素(P<0.05) 。结论:合并糖尿病、长期使用抗菌药物及合并使用糖皮质激素为 ICU COPD 患者并发真菌感染的独立危险因素。严格控制 COPD患者基础疾病,减少并控制广谱抗菌类和糖皮质激素类药物的使用和疗程,可降低真菌感染的发生。
Objective:To explore the risk factors of complicated fungal infection in ICU patients with chronic obstructive pulmonary disease(COPD).Method:The clinical data of 217 patients with COPD admitted to the ICU of our hospital from March 2018 to March 2019 were retrospectively analyzed.They were divided into the fungal infection group(n=48)and the non-fungal infection group(n=169)according to whether complicated fungal infection.The independent risk factors of complicated fungal infection in ICU patients with COPD were analyzed.Result:There were no statistically significant differences between the two groups in gender,age,BMI,COPD grading and whether complicated hypertension and right heart failure(P>0.05).Whether complicated hyperglycemia,duration of antibiotic use and whether use glucocorticoid between the two groups were compared,the differences were statistically significant(P<0.05).Diabetes mellitus,antibiotic use time≥10 d and combined use of glucocorticoids were independent risk factors for complicated with fungal infection in ICU patients with COPD(P<0.05).Conclusion:Diabetes mellitus,long-term use of antibiotics and glucocorticoids were independent risk factors for complicated with fungal infection in ICU patients with COPD.Strict control of basic diseases in patients with COPD,reduce and control the use and treatment of broad-spectrum antibacterial and glucocorticoid drugs,can reduce the incidence of fungal infection.
作者
刘瑞云
LIU Ruiyun(Laixi People’s Hospital,Laixi 266600,China)
出处
《中国医学创新》
CAS
2020年第16期63-66,共4页
Medical Innovation of China
关键词
慢性阻塞性肺疾病
真菌感染
Chronic obstructive pulmonary disease
Fungal infection
