摘要
视神经脊髓炎谱系疾病(NMOSD)是以视神经和脊髓炎性脱髓鞘损害伴轴索变性坏死为特征的中枢神经系统自身免疫性疾病,具有高复发率和高致残性的特点。近年来,随着对NMOSD发病机制的研究深入,相关的免疫治疗方法也得到迅速发展。这些免疫治疗策略统称为疾病修饰治疗,用以改善疾病的进程和转归。本文就NMOSD的最新治疗进展做一综述,以期指导临床中选择和应用疾病修饰药物(DMD)。
Neuromyelitis optica spectrum disorder（NMOSD） is an autoimmune disease of the central nervous systemthat is characterized by inflammatory demyelinating lesions and axonal degeneration in optic nerve and spinal cord. It hashigh relapse rate and high disability rate. In recent years, as the studies on mechanisms of NMOSD, related immune therapystrategies have been developed rapidly. These immunologic interventions are collectively called the disease modifyingtherapy, which are helpful in improving the course and outcome of the disease. In this review, the latest treatment progress inNMOSD is summarized to guide clinical choice and application of the medication.
出处
《天津医药》
CAS
2017年第1期100-103,共4页
Tianjin Medical Journal
基金
国家自然科学基金青年项目(81601019)
