期刊文献+

氨基酸转运体组分SLC3A2在肿瘤发生发展中的作用 被引量:4

Research Advances of Solute Carrier Family 3 Member 2(SLC3A2) in Tumor
下载PDF
导出
摘要 SLC3A2(solute carrier family 3 member 2)是来自SLC3家族的一种Ⅱ型跨膜糖蛋白,是氨基酸转运体(heteromericamino acid transports,HATs)的重链组成部分。HATs在细胞中广泛表达并介导了几乎所有必需氨基酸的跨膜转运,保证细胞内氨基酸水平的稳定,对维持细胞正常的生物学功能具有重要作用。越来越多的研究报道,SLC3A2在多种肿瘤中高表达并参与细胞的恶性转化,然而其具体作用机制仅有初步报道尚未阐明。现就SLC3A2的结构、功能及其在肿瘤发生发展过程中的作用机制等综述如下。 Solute carrier family 3 member 2(SLC3A2) is a member of type Ⅱ transmembrane glycoprotein of the SLC3 family and a component of heteromericamino acid transports(HATs).While widely expressed in cells,HATs mediate the transmembrane transport of all essential amino acids and maintain the intracellular stability of amino acid concentrations,which is important to the normal function of cells.Researches show that SLC3A2 is highly expressed in various tumor cells and involved in the malignant transformation of cells.However,the mechanisms are still lacking.In this review,we will discuss the advances in the structure and function of SLC3A2 and its mechanism in tumor occurrence and development.
出处 《肿瘤防治研究》 CAS CSCD 北大核心 2017年第3期236-240,共5页 Cancer Research on Prevention and Treatment
关键词 SLC3A2 氨基酸转运体 整合素 肿瘤 SLC3A2 HATs Integrin Tumor
  • 相关文献

同被引文献39

引证文献4

二级引证文献9

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部