摘要
氨基酸通过调控基因表达和信号传导调节细胞生理学功能.氨基酸调控基因表达的研究已有很多,但人们对真核细胞感应氨基酸的营养信号尚未了解透彻.本文综述氨基酸转运载体介导的营养信号启动、mTORC1信号通路以及细胞生长和蛋白质合成的生理效应的最新研究进展,希望在营养学或药理学方面,为干预和治疗肠道疾病及疾病引起的肌肉耗损提供理论指导.
Amino acid availability regulates cellular physiology by modulating gene expression and signal transduction pathways. Although the regulations of amino acid availability on gene expression have become increasingly well documented, the nutrient signaling of eukaryotic cells sensing amino acid has not been defined. Thus, this review summarizes recent progress in the initiation of nutrient signaling, mTORC1 signaling pathway and physiological effect about cell growth and protein synthesis induced by amino acid transporters, which would be possible to provide a support for prevention and treatment of intestinal diseases and muscular wasting in nutrition and pharmacology.
出处
《中国科学：生命科学》
CSCD
北大核心
2012年第9期699-708,共10页
Scientia Sinica(Vitae)
基金
国家自然科学基金(批准号:31001016
31110103909)
国家重点基础研究发展计划(批准号:2012CB124704)
中国科学院院长奖获得者科研启动专项资金资助项目
