摘要
青蒿素及其衍生物的抗肿瘤作用已成为近年来研究热点。青蒿素及其衍生物主要通过阻滞肿瘤细胞周期、促进肿瘤细胞凋亡、抑制肿瘤血管生成等发挥抗肿瘤作用,其对有关信号通路的影响已经引起学者们的广泛研究兴趣。目前已有许多研究者致力于新型青蒿素衍生物的合成与开发,以期发现具有更好疗效的化合物。此外,青蒿素及其衍生物逆转肿瘤耐药性的研究也成为重要发展趋势之一。本文对最近5年来青蒿素及其衍生物的抗肿瘤研究进行了述评和展望。
The antitumor activities of artemisinin and its derivatives has become a hot topic in recent years.Artemisinin and its derivatives have been reported to exert antitumor effects mainly by blocking the cell cycle, promoting tumor cell apoptosis, inhibiting angiogenesis and so on.Also, their influence on signaling pathways has attracted considerable interest of many scholars.Currently, in order to discover some compounds with better therapeutic potentials, many studies dedicated to the synthesis and development of new artemisinin derivatives.In addition, the effects of artemisinin and its derivatives on multi-drug resistantace in tumor cells also become a trend of the future research.In this paper, we review the research advances in the antitumor activities of artemisinin and its derivatives during the past five years to provide a reference for future study .
出处
《中国生化药物杂志》
CAS
2017年第3期10-14,共5页
Chinese Journal of Biochemical Pharmaceutics
基金
国家自然科学基金(81073004,81102771)
广东省自然科学基金(2014A030313385)
