摘要
青蒿素是从菊科蒿属植物黄花蒿中分离得到的倍半萜内酯,具有显著的截疟、消炎、抗肿瘤等生物活性。但其具有溶解度低、生物利用度差、结构不稳定等缺点,因此青蒿素衍生物蒿甲醚、青蒿琥酯、双氢青蒿素等应运而生,得以改善以上缺点。目前,青蒿素及其衍生物的抗肿瘤活性受到了广泛关注,并针对其作用机制展开深入研究,科学地解释了其抗癌的特异性和高效性。此外,为了提高青蒿素及其衍生物的生物利用度,还设计了一系列纳米药物递送系统,将其精准地靶向到肿瘤部位,提高其药效。总结和展望了青蒿素及其衍生物的抗肿瘤机制以及新型纳米制剂,以期对青蒿素的研究和新药研发提供帮助。
Artemisinin is a sesquiterpene lactone isolated from Artemisia annua L.,family Asteraceae,with remarkable biological activities such as malaria interception,anti-inflammatory and anti-tumor.However,it has the disadvantages such as low solubility,poor bioavailability,and unstable structure.Thus,artemisinin derivatives such as artemether,artesunate,and dihydroartemisinin have been developed to overcome the above shortcomings.At present,the anti-tumor activity of artemisinin and its derivatives has received widespread attention,and in-depth studies have been carried out on their mechanism of action,scientifically explaining their anticancer specificity and efficiency.In addition,to improve the bioavailability of artemisinin and its derivatives,a series of nano-drug delivery systems have been designed to precisely target the tumor sites and enhance their therapeutic efficacy.In this regard,the anti-tumor mechanisms of artemisinin and its derivatives as well as novel nanoformulations were summarized,aiming to provide support for further research and new drug development based on artemisinin.
作者
胡晓娴
赵雨
王赟
徐晓
韩超
HU Xiao-xian;ZHAO Yu;WANG Yun;XU Xiao;HAN Chao(School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 210000,China)
出处
《化学试剂》
CAS
2024年第7期11-19,共9页
Chemical Reagents
基金
中央高校基本科研业务费专项资金资助项目(2632021ZD24)。
关键词
青蒿素
青蒿素衍生物
恶性肿瘤
抗肿瘤机制
纳米药物递送系统
artemisinin
artemisinin derivatives
malignant tumors
anti-tumor mechanism
nano-drug delivery system
