摘要
阿尔茨海默病(AD)即老年性痴呆已成为威胁人类健康的第三大疾病。记忆障碍是本病明显的临床表现。近来已有大量研究显示,针刺治疗记忆障碍具有独特的优势,并对针刺改善AD动物记忆障碍进行了报道。结合此项目研究进展,对针刺改善记忆障碍的机制进行概述,并从针刺降低Aβ含量、降低tau蛋白表达、增强突触传递、提高胆碱能神经元活性、增加单胺类神经递质含量、抗氧化、保护神经元、促进脑内神经营养因子表达等方面,阐述针刺改善痴呆模型动物记忆障碍的有效性。
Alzheimer＇s disease（AD）, also called senile dementia, has been the third main disease threatened human health. As major clinical manifestation in AD, memory dysfunction could be treated well by acupuncture which has distinctive advantage for this kind of disease. Recently, there are many studies reported that acupuncture improved memory in AD model. In combined with our researching progress, we reviewed mechanisms of acupuncture for improving memory dysfunction in AD models in terms of reducing Aβ and tau level, enhancing synaptic transmission, promoting cholinergic neurons activity, increasing monoamine neurotransmitter level, antioxidant, protecting neurons from injury and promoting brain neurotrophic factors expression. Based on above research results, acupuncture is effective for improving memory dysfunction in AD animal model.
出处
《中国医学装备》
2017年第3期147-150,共4页
China Medical Equipment
基金
国家自然科学基金青年科学基金(81603321)"基于突触后膜受体调控的开心散改善Aβ所致突触可塑性抑制的机制研究"
黑龙江省自然科学基金(H2016072)"开心散改善Aβ所致记忆障碍的突触机制研究"
黑龙江省博士后资助项目(LBH-Z13200)"针刺补肾改善性腺切除动物记忆障碍的机制研究"
黑龙江中医药大学科研基金(2015bs04)"开心散改善神经元信息传递可塑性的突触后膜机制研究"
关键词
针刺
老年性痴呆
记忆障碍
阿尔茨海默病
Acupuncture
Senile dementia
Memory dysfunction
Alzheimer＇s disease
