摘要
目的:探讨中老年慢性阻塞性肺疾病急性加重期并发感染患者血清PCT及CRP的临床价值。方法:选择2014年12月至2016年4月符合纳入标准的中老年慢性阻塞性肺疾病患者127例,按照病情分为COPD缓解组(缓解组)以及COPD急性加重组(加重组),其中COPD急性加重组按照患者有无感染的情况再分为COPD急性加重并发感染(感染组)以及COPD急性加重未并发感染(无感染组),感染组再根据患者的肺功能进行分级。比较各分组以及分级之间的血清PCT以及CRP的水平以及变化。结果:COPD急性加重期血清PCT及CRP的水平均较COPD稳定期显著升高(P<0.05)。COPD感染组的PCT及CRP水平较非感染组的PCT及CRP水平显著升高(P<0.05)。急性加重期并发感染患者血清PCT及CRP水平在肺功能分级Ⅰ级、Ⅱ级、Ⅲ级患者中,呈逐渐上升趋势,且不同分级之间统计均有显著性差异(P<0.05)。结论:COPD急性加重期合并感染患者的血清PCT及CRP水平显著升高,且随着肺功能的恶化,血清PCT及CRP水平升高更显著。
Objective： To explore the clinical value of serum procalcitonin and C-reactive protein on middle-aged and elderly chronic obstructive pulmonary with acute aggravating concurrent infection. Methods：127 cases patients of chronic obstructive pulmonary disease met the inclusion criteria were chose in our hospital from December 2014 to April 2016,according to patient ＇ s condition,divided the COPD disease remission group（ remission group） and COPD acute aggravating group（ aggravating group）. Then subdivided into COPD with acute aggravating infection group（ infection group） and COPD with acute aggravating infection-free group（ infection-free group） at the COPD acute aggravating group,infection group was graded according to the patient＇s lung function. The different level of serum PCT and CRP on different grouping and classification were compared. Results： The levels of CRP and serum PCT at COPD acute aggravating group was significantly higher than those in stable phase（ P〈0.05）. The level of PCT and CRP at COPD with acute aggravating infection group was significantly increased than infection-free group（ P〈0.05）. The level of PCT and CRP at level Ⅰ,Ⅱ,Ⅲ lung grade function of COPD with acute aggravating infection group,showed a gradual upward trend,and the statistical difference was significant between different classification（ P〈0.05）. Conclusion： The level of serum PCT and CRP on COPD with acute aggravating infection group are significantly increased,and increase more significantly with the deterioration of lung function.
出处
《河北医学》
CAS
2017年第2期278-280,共3页
Hebei Medicine
基金
北京市海淀区科技发展计划
(编号:K20110067)
关键词
慢性阻塞性肺疾病
急性加重期
血清降钙素原
C反应蛋白
感染
Chronic obstructive pulmonary disease
Acute aggravating
Serum procalcitonin
Creactive protein
Infection
