摘要
目的探讨T2DM患者血清胱抑素C(Cys-C)与心率变异性(HRV)的相关性。方法选取T2DM患者222例,根据Cys-C分为高Cys-C(n=112)和低Cys-C组(n=110)。免疫比浊法检测Cys-C,24h动态心电图评估HRV。结果高Cys-C组5min心搏间期均值的标准差(SDANN)低于低Cys-C组[109(89,136)vs 132(105,187)m/s,P<0.05]。多元线性回归分析显示,Cys-C(log)与SDANN(log)(β=-0.395,P<0.01)、低频/高频(LF/HF)(log)(β=-0.141,P<0.01)、总功率TP(log)(β=-0.174,P<0.01)独立相关。结论 T2DM患者血Cys-C与HRV指标(SDANN、LF/HF、TP)呈负相关,提示高Cys-C与糖尿病心脏自主神经病变(DCAN)相关。
Objective To investigate the relationship between serum cystatin C（Cys-C）and heart rate variability（HRV）in patients with type 2diabetes mellitus（T2DM）. Methods 222T2 DM patients were enrolled in this cross-sectional study.Patients were divided into two groups according to the levels of serum Cys-C：the higher group（n=112）and the lower group（n=110）.Serum Cys-C was determined by immune-turbidimetric method.24-h Holter monitoring was performed for HRV analysis. Results The higher Cys-C group had less SDANN than the lower Cys-C group[109（89,136）vs 132（105,187）m/s,P〈0.05].In multiple linear regression,Cys-C（log）was independently associated with SDANN（log）（β=-0.395,P〈0.01）,LF/HF（log）（β=-0.141,P〈0.01）and TP（log）（β=-0.174,P〈0.01）.Conclusion Reduced HRV parameters（SDANN,LF/HF,TP）,which reflect cardiovascular autonomic imbalance,are closely related to serum Cys-C in T2 DM.These findings means high level of Cys-C is associated with DCAN（diabetic cardiac autonomic neuropathy）.
作者
石薇
张静
段微
陈晓蕾
SHI Wei ZHANG Jing DUAN Wei et al(Department of Endocrinology, Hubei Integrated TCM ＆ WM Hospital , Wuhan 430015 ,China)
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2017年第3期245-249,共5页
Chinese Journal of Diabetes
关键词
血清胱抑素C
糖尿病
2型
心率变异性
心脏自主神经病变
Cystatin C（Cys-C）
Diabetes mellitus,type 2
Heart rate variability（HRV）
Cardiac autonomic neuropathy（CAN）
