摘要
目的探讨NF-κB和TLR4在慢性萎缩性胃炎中的表达及意义。方法选取我院2015年3月至2016年3月期间收治的慢性胃炎和胃癌患者192例,分为A组(69例,慢性非萎缩性胃炎)、B组(65例,慢性萎缩性胃炎)和C组(58例,胃癌)。采用免疫组化SP法分别检测三组患者胃黏膜中NF-κB和TLR4的表达水平。结果 A组和B组的NF-κB和TLR4阳性率比较差异均无统计学意义(P>0.05),而C组的NF-κB和TLR4阳性率显著高于A组和B组,差异均有统计学意义(P<0.05)。结论慢性萎缩性胃炎患者NF-κB和TLR4表达水平的提高与胃癌的发生和发展有显著相关性,在慢性萎缩性胃炎患者中定期检查NF-κB和TLR4表达水平对胃癌的早期发现具有重要临床意义。
Objective To explore the expression and significance of NF-κB and TLR4 in chronic atrophic gastritis. Methods 192 cases of patients with chronic gastritis or gastric cancer admitted to our hospital from March 2015 to March 2016 were selected and divided into group A （69 cases, chronic non-atrophic gastritis）, group B （65 cases, chronic atrophic gastritis） and group C （58 cases, gastric cancer）. Immtmohistochemical SP method was used to test the expression levels of NF-κB and TLR4 in gastric mucous membrane of patients in these groups. Results No statistical difference was found in the positive rates of NF-κB and TLR4 between group A and group B （P〉0.05）, but the positive rates of NF-κB and TLR4 of group C were significantly higher than those of group A and group B, with statistical differences （all P 〈0.05）. Conclusions The increased expression levels of NF-κB and TLR4 of patients with chronic atrophic gastritis are significantly related to the occurrence and development of gastric cancer. For patients with chronic atrophic gastritis, the regular examination of expression levels of NF-κB and TLR4 is of great clinical significance to the early discovery of gastric cancer.
出处
《临床医学工程》
2017年第3期363-364,共2页
Clinical Medicine & Engineering
