摘要
目的:总结国内外关于非可控性炎症和肿瘤细胞上皮间质转化关系的研究进展,探讨非可控性炎症在肿瘤细胞恶性转化中的作用及可能机制。方法:应用PubMed及CNKI期刊全文数据库系统,以"上皮间质转化(Epithelial-mesenchymaltransition,EMT)、非可控性炎症及肿瘤微环境"为关键词,检索2005-01-2010-12的相关文献。纳入标准:1)非可控性炎症与肿瘤的联系;2)EMT与肿瘤的关系;3)非可控性炎症对EMT的调控机制。根据纳入标准分析26篇文献。结果:在非可控性炎症状态下,TGF-β、TNF-α和ILs等细胞因子可通过NF-κB等信号通路,激活EMT相关转录因子,启动并维持肿瘤细胞EMT过程,增强肿瘤细胞的侵袭性和转移性;肿瘤细胞发生EMT后又可进一步促进肿瘤微环境的形成,以维持炎症的非可控性状态。结论:非可控性炎症与EMT之间关系十分密切,通过靶向抑制非可控性炎症-EMT信号网络中的关键节点以阻断EMT过程,有望为肿瘤防治提供新的途径。
OBJECTIVE：To summarize the research advancement of the relationship between nonresolving inflammation and epithelial-mesenchymal transition in tumor,and discuss the role and probable mechanism of nonresolving inflammation in malignant transition of tumor cells.METHODS： By PubMed and CNKI retrieval system,with ＂epithelial-mesenchymal transition（EMT）,nonresolving inflammation and tumor microenvironment＂ as Key words：,papers from 2005-01 to 2010-12 were obtained.Twenty-six papers of literature are selected and analyzed according to the inclusion criteria as follows： 1）The relationship between nonresolving inflammation and tumor;2）The relationship between nonresolving inflammation and EMT;3）Mechanisms of EMT regulated by nonresolving inflammation.RESULTS： In nonresolving inflammatory status,inflammatory cytokines such as TGF-β,TNF-α and ILs can initiate and maintain the EMT process of tumor cells,which enhances their invasive and migratory ability,by activating the transcription factors associated with EMT through NF-κB signaling pathway.Furthermore,EMT promotes construction of the inflammatory tumor microenvironment.CONCLUSIONS： Nonresolving inflammation and EMT are tightly related in tumor,and inhibition of EMT through targeting the key components of the Nonresolving Inflammation-EMT signaling network probably be novel strategies for the prevention and treatment of tumor in the future.
出处
《中华肿瘤防治杂志》
CAS
2011年第17期1417-1420,共4页
Chinese Journal of Cancer Prevention and Treatment
基金
国家自然科学基金(81072005)
上海市科委项目(09410705400
10ZR1423300)
关键词
非可控性炎症
上皮间质转化
肿瘤微环境
综述文献
nonresolving inflammation
epithelial-mesenchymal transition
tumor microenvironment
review literature
