摘要
目的了解广东省急性乙型病毒性肝炎(乙肝)感染的可能影响因素,为预防控制新发乙肝提供科学依据。方法采用1∶1配对的病例对照研究。选取广东省6个乙肝监测点确诊的新发乙肝患者作为病例,选取同性别、年龄±1岁、HBs Ag和抗-HBs 2项指标同时阴性者作为对照,进行既往肝病史、6个月内输/献血史、医源性接触史、免疫史、生活接触史等问卷调查,对调查结果进行单因素和多因素logistic回归分析。结果 2013年1月至2015年8月广东省6个乙肝监测点共报告确诊急性乙肝病例213例,完成病例对照配对123对,其中男性90对,女性33对;病例组平均年龄为(42.02±18.11)岁,对照组为(42.46±17.98)岁,2组的年龄构成一致(P>0.05)。多因素logistic回归分析显示,乙肝疫苗接种史是急性乙肝感染的保护因素,OR=0.013(95%CI:0.001~0.169);既往肝病史、家庭(宿舍)内有乙肝患者或乙肝病毒携带者、肌肉或静脉注射是急性乙肝感染的危险因素,OR值分别为152.144(95%CI:11.473~2 017.590)、5.182(95%CI:1.073~25.033)和21.097(95%CI:3.407~130.656)。结论接种乙肝疫苗是急性乙肝感染的保护因素,而既往肝病史、家庭(宿舍)内有乙肝患者或乙肝病毒携带者、肌肉或静脉注射是急性乙肝感染的危险因素。建议高危人群尽早接种乙肝疫苗。
Objective To understand possible factors influencing infection of acute hepatitis B （AHB） in Guangdong Province so as to provide scientific basis for prevention and control of it. Methods A 1：1 matched case-control study was conducted. Patients with newly diagnosed AHB in 6 hepatitis B （HB） surveillance sites in Guangdong Province were selected as the case group and individuals matched by the same gender,age （ ＋ 1 year） ,and with both negative HBsAg and anti-HBs were selected as the controis. Participants were asked to complete a questionnaire about their histories of liver disease, blood transfusion/donation within 6 months,iatrogenic exposure,immunization, and life contact. Univariate and multi- variate logistic regression models were used to analyze the data. Results From January 2013 to August 2015, 213 cases of AHB were reported by six surveillance sites in Guangdong Province. A total of 123 cases-control pairs （90 male pairs and 33 female pairs） were included in the final analysis. The average age was （42.02 ± 18.11 ） years for the cases and （42.46± 17.98 ） years for the controls. Age structures between the two groups were consistent （ P 〉 0.05 ） . Multivariate logistic regression showed that history of HB vaccination （ OR：0. 013,95% CI： 0.001 -0. 169） was a protective factor for AHB,while liver disease history（ OR：152. 144,95% CI： 11. 473 -2 017. 590）, patients with HB or HB carriers in the family （dormitory） （ OR： 5. 182,95 % CI： 1. 073 - 25. 033 ） and muscle/intravenous injection （ OR ： 21. 097,95 % CI：3. 407- 130. 656） were risk factors for AHB. Conclusion HB vaccination was a protective factor for AHB. Liver disease history, HB patients or carriers in the family （ donnitory）, and muscle/intravenous injection were risk factors. High-risk groups should be vaccinated with HB vaccines as soon as possible.
作者
梁剑
邵晓萍
郑慧贞
徐新
吴承刚
LIANG Jian SHAO Xiao-ping ZHENG Hui-zhen XU Xin WU Cheng-gang(Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China)
出处
《华南预防医学》
2017年第1期17-22,共6页
South China Journal of Preventive Medicine
基金
国家科技重大专项(2012ZX10002001)
关键词
肝炎
乙型
病例对照研究
因素分析
统计学
Hepatitis B type
Case-control study
Factor analysis,statistical
