摘要
目的探讨在产前筛查中联合检测促甲状腺激素(TSH)及甲状腺过氧化物酶抗体(TPOAb)的意义。方法选取我院收治的400例孕妇进行分组对照研究,其孕周均为16~24周,以TSH值在0.25~4.00μIU/m L之间为正常范围,将400例孕妇分为甲状腺功能紊乱组215例与非甲状腺功能紊乱组185例,分别采用免疫放射法与电化学发光免疫分析法检测并对比两组的血清TSH和TPOAb水平。结果甲状腺功能紊乱组的TPOAb阳性率为79.5%,显著高于非甲状腺功能紊乱组的17.3%(P<0.05)。与TPOAb阴性组比较,TPOAb阳性组的TSH水平明显较高(P<0.05)。结论联合检测促甲状腺激素及甲状腺过氧化物酶抗体在孕妇产前筛查中具有重要意义,需要给予高度重视。
Objective To explore the clinical significance of combined detection of thyroid stimulating hormone （TSH） and thyroid peroxidase antibody （TPOAb） in prenatal screening. Methods 400 cases of pregnant women with gestational age from 16 to 24 weeks admitted to our hospital were selected for controlled clinical study. Based on the normal range of TSH of 0.25 - 4.00 μIU/mL, 400 cases were divided into thyroid dysfunction group （n = 215） and normal thyroid function group （n = 185）. The TPOAb was measured with electrochemiluminescence immunoassay, and the serum TSH was measured with radioimmunoassay. The serum TSH and TPOAb were compared between two groups. Results The positive rate of TPOAb of thyroid dysfunction group was 79.5%, significantly higher than 17.3% of normal thyroid function group, with statistical difference （P 〈0.05）. The TSH level of TPOAb-positive group was significantly higher than that of TPOAb-negative group, with statistical difference （P 〈0.05）. Conclusions Combined detection of thyroid stimulating hormone （TSH） and thyroid peroxidase antibody （TPOAb） in prenatal screening has important significance, which needs high priority.
出处
《临床医学工程》
2017年第2期229-230,共2页
Clinical Medicine & Engineering
关键词
产前筛查
促甲状腺激素
甲状腺过氧化物酶抗体
Prenatal screening
Thyroid stimulating hormone （TSH）
Thyroid peroxidase antibody （TPOAb）
