摘要
目的：探讨孕期检测促甲状腺激素（TSH）、甲状腺过氧化物酶抗体（TPO-AB）、游离甲状腺激素（FT4）及游离三碘甲状腺原氨酸（FT3）对母胎并发症的影响。方法：选取2013年1月-2014年1月在宜昌市第一人民医院进行产前检查的孕中期孕妇200例,检测所有孕妇的TSH、TPO-AB、FT4及FT3水平,同时评估其产时并发症及新生儿并发症情况。结果：200例孕妇中正常61例（对照组）,筛查出异常139例（病例组）,包括临床甲状腺功能减退30例、亚临床甲状腺功能减退25例、临床甲状腺功能亢进20例、亚临床甲状腺功能亢进34例、单纯TPO-AB阳性30例;病例组贫血、妊娠期糖尿病、妊娠期高血压疾病及产后出血等并发症发生率显著高于对照组,差异具有统计学意义（P〈0.05）;病例组早产儿、低体重儿、发育迟缓、新生儿呼吸窘迫及死胎等并发症发生率显著高于对照组,差异具有统计学意义（P〈0.05）。结论：孕期筛查TSH、TPOAB、FT4及FT3可降低产时并发症及围产儿并发症,值得临床推广。
Objective： To explore the effects of thyroid stimulating hormone（ TSH）,thyroid peroxidase antibody（ TPO-AB）,free thyroxine（ FT4）,and free triiodothyronine（ FT3） detection during pregnancy on maternal and fetal complications. Methods： Two hundred pregnant women during the second trimester of pregnancy receiving prenatal examination in the hospital from January 2013 to January2014 were selected,the levels of TSH,TPO-AB,FT4,and FT3 were detected; the intrapartum complications and neonatal complications were evaluated. Results： Among 200 pregnant women,61 women were normal（ control group）,and 139 women were found with abnormalities（ case group）,including 30 patients with clinical hypothyroidism,25 patients with subclinical hypothyroidism,20 patients with hyperthyroidism,34 patients with subclinical hyperthyroidism,and 30 patients with simple positive TPO-AB; the incidence rates of anemia,gestational diabetes mellitus,hypertensive disorder complicating pregnancy（ HDCP）,and postpartum hemorrhage in case group were statistically significantly higher than those in control group（ P〈0. 05）; the incidence rates of premature birth,low birth weight,developmental retardation,neonatal respiratory distress,and stillbirth in case group were statistically significantly higher than those in control group（ P〈0. 05）.Conclusion： TSH,TPO-AB,FT4,and FT3 detection during pregnancy can reduce intrapartum and perinatal complications,joint detection of the four indexes is worthy of clinical promotion.
出处
《中国妇幼保健》
CAS
2015年第12期1835-1836,共2页
Maternal and Child Health Care of China
基金
2009~2010年度湖北省卫生厅科研指导性项目〔JX4C28〕
