摘要
目的评估他汀类药物的多效性能否减少谵妄的发生。方法检索2000年1月至2016年6月Pub Med、万方数据库、Cochrane library、EMBase、维普中文数据库、中国期刊全文数据库收录的关于他汀类药物使用能否减少谵妄发生的随机对照试验文献,以"谵妄,ICU谵妄,他汀,辛伐他汀,阿托伐他汀,西立伐他汀,氟伐他汀,洛伐他汀,美伐他汀,普伐他汀,罗素伐他汀,HMG-Co A还原酶阻滞剂"等为检索词检索,使用Jadad量表对纳入的文献进行严格的质量评价,主要评估指标为使用他汀类药物是否有效,次要评估指标包括住院时间,机械通气的例数,最后用Rev Man5.2统计软件进行系统分析。结果共纳入7项研究,290 274例患者。其中,显示服用他汀类药物不能减少谵妄的发生率(OR:1.01;95%CI:0.81~1.26),也不能缩短住院时间(WMD:1.93;95%CI:-5.62~9.47)。但是,他汀类药物能够减少危重患者机械通气的发生率(OR:0.65;95%CI:0.47~0.90)。结论使用他汀类不能减少谵妄的发生。
Objective To evaluate whether the pleiotropic effects of statins could reduce the occurrence of delirium. Methods The published randomized-controlled trials involved about whether or not statins use reducing risk of delirium were searched from such databases as PubMed, Wanfang, Cochrane library, EMBase, VIP and CNKI, dating from Jan 2000 to Jun 2016, with the searching words of delirium, ICU delirium, statin（ s） , simvastatin, atorvastatin, cerivastatin, fluvastatin, lovastatin, mevastatin, pravastatin, rosuvastatin and HMG-CoA reductase inhibitor（s）. The collected literatures were strictly assessed by the Jadad scale, and the primary quality indicator was the effi-cacy of statins, with the secondary indicators of hospital stays and cases of mechanical ventilation. The systematic analysis was performed by software RevMan 5. 2. Results There were 7 trials, 290274 participants included, which showed that taking statins was neither associated with the incidence rate of delirium （ OR：1. 01;95%CI 0. 81~1. 26 ） , nor associated with shorter hospital stays （ WMD：1. 93;95%CI -5. 62~9. 47）. However, statins use could reduce the cases of mechanical ventilation in the critical patients （ OR：0. 65; 95%CI 0. 47 ~0. 90）. Conclusion Statins use could not reduce the occurrence of delirium.
出处
《安徽医学》
2017年第2期169-173,共5页
Anhui Medical Journal
