摘要
目的探讨雄激素受体在乳腺癌中的表达及临床意义。方法采用免疫组织化学法检测212例乳腺癌标本雄激素受体(AR)的表达状态,分析AR与雌激素受体(ER)、孕激素受体(PgR)、人类表皮生长因子受体2(HER-2)、Ki-67表达的相关性,结合肿瘤的组织学分级、淋巴结转移状态、分子亚型、病理分期初步探讨AR可能的临床意义。结果 AR在本组乳腺癌中的阳性表达率为64.2%。分子亚型不司,AR的表达存在差异:在Luminal A型乳腺癌中AR表达率最高(78.0%),在三阴性乳腺癌中最低(35.3%),差异有显著性(χ~2=17.316,P=0.001);AR表达率与淋巴结转移个数、肿瘤病理分期呈负相关(P均<0.05);AR在ER阳性的乳腺癌中阳性表达率为73.2%,两者表达具有相关性(r=0.242,P=0.000)。Ki-67指数越高,AR阳性表达率越低(r=-0.201,P=0.004)。AR的表达与患者年龄、乳腺癌组织学分级、肿瘤大小以及PgR、HER-2的表达状态无关(P均>0.05)。结论 AR在乳腺癌中具有较高的阳性表达率,在乳腺癌不同亚型中存在差异,与传统的预后因素有一定的相关性,提示AR可以作为乳腺癌的预后指标或新的治疗靶点。
Objective To explore the potential relationship between androgen receptor（AR）and the prognosis lactors of breast cancer.Method To detect the expression of AR in 212 breast cancer tissues by immunohistochemical staining,and to analyze the distribution of AR and the relationship between AR and clinicopathological factors,such as age,molecular subtypes,histological grading,tumor size,lymph node staging,pathological staging,ER,PgR,HER-2,and Ki-67.Result A total of 136 cases（64.2%）showed a positive immunostaining of AR,but with a wide variation in the staining score values and staining intensity.There are great significances of AR expression among different molecular subtypes,78.0%positive rate of AR in luminal A subtype,and 35.3%positive rate of AR in triple negative subtype（χ~2= 17.316,P = 0.001）.AR expression was negative correlated with the node status（r =-0.307,P =0.000）.pathological stage（r=-0.261,P = 0.000）,Ki-67 staining score values（r=-0.201,P = 0.004）,and positive correlated with ER staining score values（r=0.242,P=0.000）.AR expression was not correlated with patients＇ age,tumor size,tumor grade,PgR and HER-2 status（P0.05）.Conclusion The high expression rate of AR and the correlationship between AR expression and classical prognostic factors of breast cancer indicates that AR plays a role in endocrinotherapy prediction and prognosis.
出处
《中国临床医生杂志》
2017年第2期32-35,共4页
Chinese Journal For Clinicians
关键词
雄激素受体
乳腺癌
预后
分子亚型
Androgen receptor
Breast cancer
Prognosis
Molecular subtype
