摘要
目的:探讨睾丸酮在乳腺癌组织及癌旁组织中的表达情况,并分析其与乳腺癌临床病理特征的关系。方法:应用酶联免疫吸附试验检测30例乳腺癌组织、癌旁2cm及癌旁5cm乳腺组织中睾丸酮的含量,进行比较研究,并分析肿瘤组织中睾丸酮含量与乳腺癌的临床病理特性的关系。结果:乳腺癌组织中睾丸酮的含量(48.31±9.40)ng/mL高于癌旁2cm(43.93±10.90)ng/mL和癌旁5cm乳腺组织的含量(44.88±9.89)ng/mL,但差异无统计学意义,F=1.565,P=0.215。乳腺癌组织学分级Ⅲ级者的睾丸酮含量(57.81±4.34)ng/mL高于Ⅱ级者(45.61±8.37)ng/mL和Ⅰ级者(41.18±6.90)ng/mL,P=0.001。绝经前乳腺癌患者乳腺癌组织中睾丸酮的含量(43.67±9.65)ng/mL低于绝经后患者(50.99±8.36)ng/mL,P=0.037。绝经后患者乳腺癌组织中睾丸酮的含量高于癌旁5cm乳腺组织中睾丸酮的含量(43.77±10.05)ng/mL,P=0.031。结论:组织学分化差、恶性程度高的乳腺癌组织中睾丸酮含量较高,绝经后妇女乳腺癌组织中睾丸酮含量高。乳腺癌组织中睾丸酮含量的检测可能有助于乳腺癌恶性程度的判断。
OBJECTIVE： To detect the concentration of testosterone in breast cancer, breast tissue away from the tumor,and analyze the relationship between the testosterone concentration and clinicobiological features. METHODS： ELISA was performed to examine the concentration of testosterone in breast cancer, breast tissues 2 cm and 5cm away from the tumor in 30 breast cancer patients. Relationship between testosterone concentration of tumor tissue and clinicobiological features was analyzed. RESULTS： The concentration of testosterone in breast cancer tissues （48. 31±9.40） ng/mL was higher than that of tissues 2 cm （43.93±10.90） ng/mL and 5 cm （44.88±9.89） ng/mL away from tumor （F= 1. 565, P=0. 215）. Testosterone concentration was higher in those with worse grade. Those with grade Ⅲ（57.81± 4. 34） ng/mL had much more testosterone than those with grade I （41. 18± 6. 90） ng/mL, H （45. 61± 8.37） ng/mL （P〈0. 001）. The testosterone concentration in premenopausal patients （43.67 ± 9.65） ng/mL was lower than those in postmenopausal patients （50.99 ±8.36） ng/mL （P = 0. 037）. In postmenopausal patients, the testosterone concentration in breast cancer was higher than those in tissue 5 cm away from tumor （43. 77± 10. 05） ng/mL （P〈0. 031）. CONCLUSIONS： Breast cancer with higher histological grade may be with higher testosterone concentration. Breast cancer in postmenopausal patients may be with higher testosterone concentration. The testosterone concentration in breast tumors may contribute to the diagnosis of the malignant status for breast cancer.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2013年第7期509-511,共3页
Chinese Journal of Cancer Prevention and Treatment
关键词
乳腺肿瘤
睾丸酮
酶联免疫吸附测定
临床病理特征
breast neoplasms
testosterone enzyme-linked immunosorbent assay linicopathological characteristic
