摘要
Objective:To investigate the expression and clinical significance of hypoxia inducible factors HIF-1a,Gli-1 and MMP9 in breast cancer.Methods:Eighty patients with invasive ductal carcinoma of the breast and 40 normal tissues adjacent to cancer were selected.Immunohistochemical methods were used to detect the expression of HIF-1a,Gli-1 and MMP9 in breast cancer and normal tissues adjacent to cancer,and their re1ationship with clinicopathological features of breast cancer and prognosis was explored.Results:The positive rates of HIF-1a,Gli-1 and MMP9 in breast cancer tissues were significantly higher than those in normal breast tissues.HIF-1a,Gli-1 and MMP9 expressions are positively corre1ated in breast cancer.Conclusion:HIF-1a,Gli-1 and MMP9 proteins are involved in the pathogenesis of breast cancer.
