摘要
目的:探讨中青年动脉粥样硬化性脑梗塞(ACI)患者血清胱抑素C(CysC)水平与脑梗塞(CI)及动脉硬化严重程度的关系。方法:选择我院2013年2月~2015年9月收治的82例中青年ACI患者为研究对象,按脑梗塞体积大小分为小梗塞组(36例)、中梗塞组(22例)和大梗塞组(24例);根据脑梗塞严重程度分为轻度CI组(54例)和重度CI组(28例);根据动脉粥样硬化斑块性质分为稳定斑块组(45例)和不稳定斑块组(37例)。另选择46例年龄相当的健康人为健康对照组。测量、比较各组急性期和恢复期血清CysC水平和颈动脉内膜中层厚度(IMT)的关系。结果:与急性期比较,ACI各亚组恢复期的血清CysC水平均显著降低(P均<0.01);与健康对照组比较,小、中和大梗塞组急性期和恢复期血清CysC水平[恢复期:(0.81±0.24)mg/L比(1.03±0.13)mg/L比(1.09±0.19)mg/L比(1.18±0.10)mg/L]均显著升高,且大梗塞组显著高于小和中梗塞组(P均<0.01)。与健康对照组比较,轻度和重度梗塞组急性期和恢复期血清CysC水平[恢复期:(0.81±0.24)mg/L比(1.07±0.15)mg/L比(1.19±0.16)mg/L]均显著升高,且重度梗塞组显著高于轻度梗塞组(P均<0.01)。与健康对照组比较,稳定斑块组和不稳定斑块组急性期血清CysC水平[(0.81±0.24)mg/L比(1.18±0.15)mg/L比(1.39±0.27)mg/L]和IMT[(0.72±0.10)mm比(1.24±0.17)mm比(1.30±0.14)mm]显著升高和增厚,且不稳定斑块组的显著高于和厚于稳定斑块组(P均<0.01)。结论:脑梗塞患者血清胱抑素C水平显著升高,可作为脑梗塞防治的指标。
Objective： To explore relationship among severity of cerebral infarction （CI）, arteriosclerosis and serum level of cystatin C （CysC） in young and middle-aged patients with atherosclerotic cerebral infarction （ACI）. Methods： A total of 82 young and middle-aged ACI patients treated in our hospital from Feb 2013 to Sep 2015 were enrolled. According to CI volume, they were divided into small infarction group （n = 36）, medium infarction group （n = 22） and large infarction group （n= 24） ; according to CI severity, they were divided into mild CI group （n= 54） and severe CI group （n= 28） ; according to atherosclerotic plaque nature, they were divided into stable plaque group （n = 45） and unstable plaque group （n = 37）. Anotber 46 healthy people were regarded as healthy control group. Serum CysC level during emergency period and recovery period and carotid intima-media thickness （IMT） were measured and compared among all groups. Results： Compared with emergency period, there was significant reduction in serum CysC level in all subgroups of ACI during recovery period, P〈0. 01 all; compared with healthy control group, there were significant rise in serum CysC level [-recovery period： （0.81±0.24） mg/L vs. （1.03±0. 13） mg/L vs. （1.09±0. 19） mg/L vs. （1.18±0. 10） mg/L] during emergency period and recovery period in small, medium and large infarction group, and that of large infarction group was significantly higher than those of small and medium infarction group （P〈0. 01 all）. Compared with healthy control group, there was significant rise in serum CysC level [recovery period.. （0.81 ± 0 24） mg/L vs. （1.07 ±0. 15）mg/L vs. （1.19 ± 0. 16） mg/L] during emergency period and recovery period in mild and severe infarction group, and that of severe infarction group was significantly higher than that of mild infarction group, P〈0. 01 all. Compared with healthy control group, there were sig-nificant rise in serum CysC level[（0. 81 ± 0.24�
作者
高利涛
王静
闫佳兰
徐玉
王丽
GAO Li-tao WANG Jing YAN Jia-lan XU Yu WANG Li(Department of Neurology, Bethune International Peace Hospital of Chinese PLA, Shijiazhuang, Hebei, 050082, Chin)
出处
《心血管康复医学杂志》
CAS
2017年第1期37-40,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
