摘要
目的探讨肝素联合氨溴索雾化吸入预防老年患者上腹部手术后肺部感染的疗效。方法回顾分析58例老年上腹部手术患者,其中观察组30例,术后给予肝素联合氨溴索雾化吸入治疗,对照组28例,给予氨溴索雾化吸入治疗,比较两组术后5 d排痰量、动脉血氧饱和度(saturation of arterial blood oxygen,Sa O2)、动脉血氧分压(arterial partial pressure of oxygen,Pa O2)、氧合指数,凝血酶原时间(prothrombin time,PT)、部分活化凝血活酶时间(activated partial thromboplastin time,APTT)、血浆D-二聚体等指标,出血并发症以及肺部感染发生率。结果观察组术后5 d排痰量、氧饱和度、动脉血氧分压、氧合指数高于对照组,血浆D-二聚体低于对照组,差异有统计学意义(P<0.05);两组凝血酶原时间、部分凝血酶原时间比较无统计学差异(P>0.05);观察组未发生肺部感染,对照组发生肺部感染4例,差异有统计学意义(P<0.05)。结论老年病人上腹部手术后使用肝素联合氨溴索雾化吸入安全性好,能促进排痰,改善呼吸功能,有效降低肺部感染发生率。
Objective To explore the efficacies of heparin combined with ambroxol atomizing inhalation for prevention of pulmonary infection in old patients with upper abdominal surgery.Methods 58 old patients were retrospectively analyzed and they were divided into the observation group（ 30 patients） and the control group（ 28patients）. The patients in the observation group were treated with heparin combined with ambroxol atomizing inhalation after surgery. The patients in the control group were treated with ambroxol atomizing inhalation. The saturation of arterial blood oxygen（ Sa O2）,arterial partial pressure of oxygen（ Pa O2）,oxygenation index,prothrombin time（ PT）,activated partial thromboplastin time（ APTT）,plasma D-dimer,the complication such as bleeding and the occurrence rate of pulmonary infection after surgery were compared between the two groups.Results The sputum volume in 5 days,Sa O2,Pa O2 and oxygenation index of the observation group were higher than that of the control group（ P〈0.05）.The plasma D-dimer was lower than that in the control group. There were no significant differences in PT and APTT between the two groups（ P〉0.05）.There was no complication such as bleeding in the observation group. The occurrence rate of pulmonary infection was lower than that in the control group,and the difference was statistically significant（ P〈0.05）. Conclusions Heparin combined with ambroxol atomizing inhalation can promoting sputum excretion and improving respiratory function. It is safety and effective for prevention of pulmonary infection in old patients with upper abdominal surgery.
出处
《齐齐哈尔医学院学报》
2016年第31期3899-3900,共2页
Journal of Qiqihar Medical University
