摘要
目的:观察中西医结合治疗慢性阻塞性肺疾病急性加重期(AECOPD)患者的临床疗效。方法:将220例AECOPD气虚痰瘀证患者根据随机配对原则分为观察组与对照组各110例,2组均给予常规治疗,对照组服用孟鲁司特钠咀嚼片治疗,观察组以益气化痰祛瘀方联合孟鲁司特钠咀嚼片治疗,2组疗程均为1月。观察2组的疗效与心肺功能、免疫功能的变化情况。结果:对照组与观察组的总有效率分别为83.6%、96.4%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组左室射血分数、第1 s用力呼气容积占预计值百分比均高于治疗前(P<0.05),观察组2项指标值均高于对照组(P<0.05)。2组CD4^+水平均较治疗前升高(P<0.05),观察组CD4+水平与对照组比较,差异有统计学意义(P<0.05)。结论:中西医结合治疗AECOPD能改善患者的心肺功能和免疫功能,有利于提高疗效与生活质量。
Objective ： To observe the clinical effect of integrated Chinese and western medicine therapy in treating patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）. Methods： Divided 220 cases of AECOPD patients with qi deficiency and phlegm stagnation syndrome into the observation group and the control group randomly, 110 cases in each group. Both groups were given routine treatment. The control group was treated with montelukast sodium chewable tablets, while the observation group was given prescription with the effect of invigorating qi and removing blood stasis, resoliving phlegm, combined with montelukast sodium chewable tablets. The two groups were both treated and observed for one month. Observed the curative effect and changes of pulmonary function and immune function in two groups. Results： The total effective rate was 83. 6 % in the control group and 96. 4 % in the observation group, the significant difference being found in the comparison between two groups（P 〈 0. 05）. After treatment, the left ventricular ejection fraction and the forced expired volume in one second in two groups were higher than those before treatment（P 〈 0. 05）, and these two indexes in the observation group were both higher than those in the control group（P〈 0. 05）. Levels of CD4~＋ in both groups were increased after treatment（P 〈 0. 05）. Compared the level of CD4＋ in the observation group with that in the control group, difference was significant（P 〈 0. 05）. Conclusion ： Integrated Chinese and western medicine therapy for AECOPD can improve cardiopulmonary function and immune function and enhance the curative effect and life quality, which is of high application value.
出处
《新中医》
CAS
2017年第2期32-35,共4页
New Chinese Medicine
关键词
慢性阻塞性肺疾病急性加重期(AECOPD)
气虚痰瘀证
中西医结合疗法
益气化痰祛瘀方
孟鲁司特钠咀嚼片
心肺功能
免疫功能
Acute exacerbation of chronic obstructive pulmonary disease（AECOPD）
Qi deficiency and phlegm stagnation syndrome
Integrated Chinese and western medicine therapy
Invigorating qi
Removing blood stasis and resoliving phlegm
Montelukast sodium chewable tablets
Cardiopulmonary function
Immune function
