摘要
目的了解医院临床标本分离金黄色葡萄球菌的分布及其耐药性变化情况,为临床合理用药提供依据。方法采用细菌分离鉴定和药敏试验方法,对某医院住院患者送检病原学标本检出金黄色葡萄球菌分布及其耐药性进行分析。结果该医院连续3年从住院患者送检标本中共分离出金黄色葡萄球菌434株,其中耐甲氧西林的金黄色葡萄球菌(MRSA)82株,占18.89%。在各类标本中以痰液分离率最高,其次是分泌物和脓液。临床分离的金黄色葡萄球菌主要分布在耳鼻喉科,其次是重症监护室(ICU)和神经外科。临床分离金黄色葡萄球菌对青霉素、氨苄西林、红霉素耐药率较高,未发现耐万古霉素菌株,MRSA的耐药率明显高于甲氧西林敏感(MSSA)菌株。结论该医院在连续3年内金黄色葡萄球菌的检出率和耐药性均无明显变化,这主要得益于严格执行感染防控措施和合理使用抗菌药物。
Objective To investigate the distributions and drug resistance changes of Staphylococcus aureus isolated from clinical samples and to provide evidences for clinical rational drug uses. Methods Bacteria isolation and identification methods and drug sensitivity test were used to analyze the distributions and drug resistance changes of Staphylococcus aureus. Results 434 strains of Staphylococcus aureus were isolated from clinical specimens in three years,including 82 strains of Methicillin resistant Staphylococcus aureus（ MRSA）,which accounted for 18. 89% of the total Staphylococcus aureus;Those Staphylococcus aureus strains were mainly isolated from sputum followed by from secretion and pus. They were mainly distributed in departments of Ear,nose and throat（ ENT） followed by in ICU and Neurosurgery department. The isolated Staphylococcus aureus had high drug resistant rates to Penicillin,Ampicillin and Erythromycin,but there was no Vancomycin resistant Staphylococcus aureus isolated. The drug resistant rate of MRSA were obviously higher than Methicillin sensitive Staphylococcus aureus（ MSSA）. Conclusion There are no significant change in the detection rate and drug resistance of Staphylococcus aureus in three years. It was mainly due to the clinicians＇ strictly implementing infection prevention and control measures and rationally using of antibiotics.
作者
王博
张淑芹
李昆
WANG Bo ZHANG Shu - qin LI Kun(The First Affiliated Hospital of Jinzhou Medical University, Jinzhou Liaoning 121000, China)
出处
《中国消毒学杂志》
CAS
北大核心
2016年第12期1210-1211,1214,共3页
Chinese Journal of Disinfection
关键词
金黄色葡萄球菌
抗菌药物
耐药性
Staphylococcus aureus
antibacterials
drug resistant
