摘要
目的研究耳鼻喉术后并发感染患者的血清炎症因子、T淋巴细胞亚群等临床指标的表达水平和临床意义,为耳鼻喉术后并发感染的临床诊治提供依据。方法选取2013年12月-2014年12月医院收治的耳鼻喉手术患者68例,根据患者术后是否并发感染分成了感染组和非感染组,各34例,对两组患者的C-反应蛋白(CRP)、白介素-8(IL-8)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和CD3+、CD4+、NK细胞百分比以及住院时间和抗菌药物使用时间进行观察和比较。结果感染组患者的CRP、IL-8、IL-6、TNF-α分别为(18.73±4.32)mg/L、(33.87±3.28)ng/ml、(30.28±4.32)ng/ml、(5.87±1.38)ng/ml,高于非感染组的(8.92±2.18)mg/L、(20.86±3.19)ng/ml、(15.97±2.39)ng/ml、(1.83±0.63)ng/ml;感染组患者的CD3+、CD4+、NK细胞百分比分别为(47.83±5.34)%、(39.28±5.43)%、(20.35±6.54)%,低于非感染组的(57.42±7.34)%、(48.34±7.53)%、(38.27±8.01)%;感染组患者的住院时间和抗菌药物使用时间分别为(10.83±1.81)d和(8.81±1.21)d,高于非感染组的(7.18±1.61)d和(5.19±1.02)d,差异均有统计学意义(P<0.05)。结论术后并发感染可导致耳鼻喉手术患者血清炎症因子水平的升高和T淋巴细胞亚群相关指标的降低,不利于患者术后恢复,针对耳鼻喉术后感染实施有针对性的预防和干预具有重要的临床意义。
OBJECTIVE To investigate the levels of expression of clinical indicators such as serum inflammatory cytokines, T lymphocyte subsets in ENT surgery patients complicated with postoperative infections so as to provide guidance for clinical diagnosis and treatment of the postoperative infections. METHODS A total of 68 patients who underwent the ENT surgery in the hospital from Dec 2013 to Dec 2014 were enrolled in the study and divided into the infection group and the non-infection group according to the status of postoperative infections, with 34 cases in each group. The levels of C-reactive protein （CRP）, interleukin-8 （IL-8）, interleukin-6（IL-6）, and tumor necrosis factora（TNF-α）, the percentages of CD3^＋ , CD4^ ＋ , and NK cell, the hospitalization duration, and the time of use of antibiotics were observed and compared between the two groups of patients. RESULTS The levels of CRP, IL-8, IL-6, and TNF-α of the infection group were respectively （18. 73±4.32）mg/L, （33.87±3.28）ng/ml, （30.28± 4.32）ng/ml, and （5. 874-1.38）ng/ml, higher than （8. 924-2.18）mg/L, （20.86±3.19）ng/ml, （15. 97±2.39） ng/ml, and （1.83±0.63）ng/ml of the non-infection group. The percentages of CD3^＋ , CD4^＋ , and NK cell of the infection group were respectively （47. 83± 5. 34） %, （39. 28 ± 5. 43）%, and （20. 35 ± 6. 54） %, lower than （57. 42±7.34）%, （48. 34±7.53） %, and （38.27±8.01）% of the non-infection group. The hospitalization duration of the infection group was （10.83±1.81） days, longer than （7.18 ±1.61） days of the non-infection group; the time of use of antibiotics of the infection group was （8.81 ±1.21） days, longer than （5.19 ±1.02） days of the non-infection group, and there was significant difference （P〈0.05）. CONCLUSION The complication with postoperative infection may lead to the elevation of levels of serum inflammatory cytokines and the reduction of levels of T lymphocyte subsets and is not beneficial to the postopera
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2017年第2期396-398,共3页
Chinese Journal of Nosocomiology
基金
河南省医学科技攻关计划指导性计划项目(201412024)
