摘要
维生素D对新生儿肺发育有重要作用。目前研究多采用美国AAP和IOM的标准定义维生索D不足（血清25-OH-D〈50nmol／L），国内研究显示新生儿维生素D缺乏的比例较高。动物实验显示1，25（OH）2D3通过影响肺泡数量、肺泡隔厚度、气道阻力、肺容量以及免疫细胞聚集，从而影响肺发育。人群研究提示维生素D缺乏新生儿需要辅助通气、呼吸窘迫综合征的比例较高，需氧时间更长。
Recent studies show that vitamin D plays a role in lung development and regulation of lung maturation in the fetus. The AAP and the Institute of Medicine（IOM） both define vitamin D insufficiency as ser- um 25-OH-D concentrations 〈 50 nmol/L in the pediatric population. The surveys in our country show the prev- alence of vitamin D insufficiency is higher according to the criteria defined by AAP. Evidence from animal study suggests that vitamin D may increase alveolar count, alveolar septal thickness, lung volume and decrease airway resistance,immune cell aggregation leading to the maturation of lung. The cohort studies suggest low 25-OH-D level in infants at birth is associated with greater need for assisted ventilation,increased rate of ARDS, increased duration of oxygen requirement
出处
《国际儿科学杂志》
2016年第12期942-945,共4页
International Journal of Pediatrics
关键词
维生素D
新生儿
肺发育
Vitamin D
Neonates
Lung development
