摘要
目的通过对使用多效唑处理后的麦冬药材进行安全性和有效性综合评价,为麦冬生产中科学、合理的使用多效唑提供理论依据。方法施用不同浓度多效唑处理麦冬植株,收集药材样品。从麦冬药材外观性状,黄酮、皂苷、多糖三大类有效成分含量各方面综合分析麦冬有效性;对多效唑残留量进行检测参照"GB2763-2014"多效唑摄入限量和《中国药典》麦冬用量评价多效唑对麦冬药材安全性的影响。结果多效唑对麦冬药材性状质量影响不显著;对麦冬多糖和黄酮含量均有不同程度的升高作用,对麦冬皂苷含量有一定的降低作用。多效唑按照3kg·亩^(-1)用量最高残留和麦冬最大用量计算,远低于每日允许摄入量(ADI:0.1 mg·kg^(-1)×体重)。结论在麦冬生产中可根据实际情况限量使用多效唑。
OBJECTIVE To provide a theoretical basis for scientific and rational use of paelobutrazol in the production of Ophiopogonis Radix. METHODS Different concentrations of paclobutrazol were applied to Ophiopogonis Radix plants, and medicinal samples were colleted. The efficacy of Ophiopogonis Radix were comprehensively analyzed from the appearance of the herb and the contents of three kinds of effective components ： flavonoids, saponins, and polysaechafides. Residues of paclobutrazol were detected. The effect of paelobutrazol use on the safety of Ophiopogonis Radix was evaluated according to the acceptable daily intake （ADI） of paclobutrazol in the GB2763-2014 and the amount of usage of paclobutrazol required by Chinese Pharmacopoeia. RESULTS Paclobutrazol had no significant effects on the Ophiopogonis Radix appearance; and the contents of polysaecharides and flavonoid were increased in varying degrees, and saponins content were decreased. The daily intake of paclobutrazol was far less than the ADI （0. 1 mg . kg -1 × body weight） when calculated using the maximum residue of paclobutrazol at the usage of 3 kg . acres-1 and the maximum usage amount of Ophiopogonis Radix in Chinese Pharmacopoeia. CONCLUSION Paelobutrazol can be used within limits according to the actual situation in Ophiopogonis Radix production.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2017年第1期20-24,共5页
Chinese Pharmaceutical Journal
基金
国家科技部重大专项课题"重大新药创制"项目子课题(2014ZX09304307-002)
科技部科技惠民项目(2013GS510102)
四川省中医管理局科研项目(2014F038)
四川省科技厅科技支撑项目(2015SZ0033)
关键词
麦冬
多效唑
有效性
安全性
黄酮
皂苷
多糖
Ophiopogonis Radix
paclobutrazol
efficacy
safety
flavonoid
saponins
polysaccharide
