摘要
目的评价厚血涂片和疟原虫快速检测(RDT)组成的平行诊断试验用于疟疾流行区归国人员疟原虫感染监测的性能。方法使用厚血涂片、RDT和巢氏PCR分别检测长沙市4家涉非洲劳务派遣单位归国人员静脉血484份,对检测结果进行统计分析。结果单独使用厚血涂片和RDT的敏感度分别为0.628和0.744,平行试验的敏感度可达到0.930;平行诊断试验ROC曲线下面积为0.930(95%CI:0.895~0.986),高于厚血涂片的0.814(95%CI:0.724~0.904)和RDT的0.847(95%CI:0.769~0.926)。结论厚血涂片和RDT组成的平行试验可以有效提高对疟疾流行区归国人员疟原虫感染者监测敏感度和准确度,值得推广应用。
Objective To evaluate the performance of parallel test in detecting malaria infection for returned person from malaria endemic area.Methods The blood samples of 484 returnees from malaria endemic area were analyzed and detected by thick blood smear,rapid diagnostic test（RDT）and nest PCR in four companies involving the African labor dispatching.Results The sensitivity of thick blood smear and RDT was 0.628 and 0.744 respectively,which of the parallel test was 0.930.On the other hand,the area under the curve（AUC）of parallel test was 0.930（95%CI：0.895-0.986）,which was higher than thick blood smear[0.814（95%CI：0.724-0.904）]and RDT[0.847（95%CI：0.769-0.926）].Conclusion Thick blood smear and RDT,which consist of parallel test,could improve the detection sensitivity and accuracy for returnees from malaria epidemical area effectively.This approach is worthy of popularization and application
出处
《国际检验医学杂志》
CAS
2017年第1期7-9,共3页
International Journal of Laboratory Medicine
基金
长沙市科技局项目(K13ZD051-33)
