摘要
目的 探讨胸腺肽α1联合CHOP方案对弥漫大B细胞淋巴瘤（DLBCL）效果、骨髓抑制和免疫功能的影响。方法 选取2013年1月-2016年3月在我院确诊的99例DLBCL初治患者作为研究对象,按照随机数字表法分为对照组（49例）和观察组（50例）。对照组采用CHOP方案化疗,观察组在对照组的基础上给予胸腺肽α1。比较两组治疗前后的外周血T细胞亚群和骨髓抑制情况以及治疗效果。结果 观察组化疗后的CD4、NK水平高于化疗前,差异有统计学意义（P〈0.05）。对照组化疗后的CD4、CD4/CD8、NK水平低于化疗前,差异有统计学意义（P〈0.05）。观察组化疗后的免疫功能改善情况优于对照组化疗后,差异有统计学意义（P〈0.05）。两组的Ⅲ-Ⅳ度骨髓抑制发生率比较,差异无统计学意义（P〉0.05）。两组的总有效率比较,差异无统计学意义（P〉0.05）。结论 胸腺肽α1能显著提高DLBCL患者的细胞免疫功能,但在提高临床效果和降低骨髓抑制方面无优势。
Objective To explore the influence of Thymosin α1 combined with CHOP regimen on effect,bone marrow suppression and immune function of diffuse large B cell lymphoma （DLBCL）.Methods 99 patients with DLBCL from January 2013 to March 2016 in our hospital were selected and divided into the control group （49 cases） and the obser- vation group （50 cases） according to the random number table method.The control group was treated with CHOP chemotherapy,while the observation group was treated with Thymosin α1 on the basis of the control group.The level of peripheral blood T cell subsets and bone marrow suppression in the two groups before and after treatment were compared and the treatment effect was compared.Results The level of CD4,NK after chemotherapy in the observation group was higher than that before chemotherapy,with significant difference （P〈0.05）.The level of CD4,CD4/CD8,NK after chemotherapy in the control group was lower than that before chemotherapy,with significant difference （P〈0.05）.The improvement of immune function after chemotherapy in the observation group was better than that in the control group af- ter chemotherapy,with significant difference （P〈0.05）.There was no significant difference in the incidence rate of bone marrow suppression of Ⅲ-Ⅳ degree between the two groups （P〉0.05）.There was no significant difference in the total effective rate between the two groups （P〉0.05）.Conclusion Thymosin α1 can significantly improve the cellular immune function in patients with DLBCL,but there is no advantage in improving curative effect and reducing the risk of bone marrow suppression.
出处
《中国当代医药》
2016年第35期59-61,共3页
China Modern Medicine
关键词
胸腺肽Α1
弥漫大B细胞淋巴瘤
免疫功能
骨髓抑制
Thymosin 1
Diffuse large B cell lymphoma
Immune function
Bone marrow suppression
