摘要
目的探讨中国人弥漫大 B 细胞淋巴瘤(DLBCL)的一般临床特点、实验室检查以及肿瘤细胞来源与预后的关系。方法收集74例 DLBCL 患者的基本临床资料、实验室检查结果,并进行石蜡切片免疫组化染色检测 Bcl-6、CD10、MUM-1等蛋白表达。临床跟踪随访,分析影响预后的相关因素。结果 74例患者中,平均年龄58.5岁,男女比例为1.64:1。23.2%(69例中16例)的患者单纯累及淋巴结,15.9%(69例中11例)的患者单纯累及结外器官。55例可追踪随访的病例中死亡13例,死亡率23.6%;其中12例在诊断后1年内死亡,占92.3%。预后分析显示:患者发病年龄>65岁(P=0.036)及国际预后指数(IPI)(P=0.009)与预后明显相关;不同肿瘤细胞来源(P=0.086)其生存曲线差异明显,但本组资料差异无统计学意义;β2微球蛋白及 Bcl-6表达与预后无明显相关性。结论 DLBCL 患病人群以中老年男性为主,1年内为死亡高发时间。发病年龄及 IPI 是明显影响预后的因素。用免疫组化方法检测不同的肿瘤细胞来源类型,对预后有一定的提示作用。
Objective To explore the relationship of clinic features, lab findings, the origin of tumor cell as well as prognosis in Chinese patients with diffuse large B-cell lymphoma（DLBCL）. Methods Seventy four cases of primarily diagnosed DLBCL were analyzed. Immunohistochemistry stain was used to check the expressions of Bcl-6,CD10 and MUM1. Results Among the 74 patients, the average age was 58.5 years, the ratio of male to female was 1.64： 1. 23.2% （ 16/69 ） cases developed in lymph node, 15.9% （ 11/ 69） in the extra node area. Among 55 follow-up cases, 13 （23.6%） died, and 12 （92.3%） died in the first year after diagnosis. The prognosis analysis showed that diagnosed at age 〉 65 years （ P = 0.036）, and the international prognostie index（IPI） （ P = 0.009） were independent prognostic factors ; origin of tumor cell had a trend to be a prognostic factor, but no statistic difference （ P = 0.086）. 132-MG and Bcl-6 expression had no relation with the prognosis. Conclusion The middle and old-aged male patients are the most common in DLBCL and the first-year mortality rate is higher. The age at diagnosis and IPI can predict the clinical outcome. The origin of tumor cell might suggest the prognosis.
出处
《中华血液学杂志》
CAS
CSCD
北大核心
2007年第10期667-670,共4页
Chinese Journal of Hematology
基金
教育部"211"工程重点学科建设资助项目
关键词
淋巴瘤
大细胞
弥漫型
乳酸脱氢酶
国际预后指数(
P
)
肿瘤细胞来源
预后
Lymphoma,large-cell, diffuse
Lactata dehydrogenase
International prognostic index （IPI）
Derived tumor cell
Prognosis
