摘要
目的分析miR-21、miR-155、miR-210的临床表达意义及其与淋巴瘤病理特征的相关性。方法选取2014年12月~2016年12月南通市肿瘤医院收治的62例经病理学证实的淋巴瘤患者作为研究对象,分别对淋巴瘤组织及正常淋巴组织中的miR-21、miR-155、miR-210表达量进行测定,同时分析miR-21、miR-155、miR-210表达量与患者年龄、性别、免疫分型、MYC基因及BCL-6蛋白表达之间的关系。结果淋巴瘤组织miR-21、miR-155、miR-210表达量较正常淋巴组织高,差异有统计学意义(P<0.05)。免疫分型中NK/T细胞淋巴瘤、黏膜相关淋巴瘤的miR-21、miR-155、miR-210表达量均高于DLBCL,MYC基因中正常排列的miR-21、miR-155、miR-210表达量均高于基因重排,BCL-6蛋白中表达的miR-21、miR-155表达量均低于未表达,差异有统计学意义(P<0.05)。miR-21、miR-155表达与淋巴瘤患者免疫分型、MYC基因及BCL-6蛋白表达有关系,miR-210表达与淋巴瘤患者免疫分型、MYC基因有关系(P<0.05)。结论 miR-21、miR-155、miR-210参与淋巴瘤的发生与进展,miR的高表达量对淋巴瘤患者预后造成一定影响,在临床上对miR-21、miR-155、miR-210表达情况进行测定,对后续治疗及预后都具有一定的指导意义。
Objective To investigate the clinical significance of miR-21, miR-155 and miR-210 and their correlation with the pathological features of lymphoma. Methods 62 cases of pathologically confirmed lymphoma patients from De- cember 2014 to December 2016 in Nantong Tumor Hospital were chosen as the research objectes. Expression of miR- 21, miR-155 and miR-210 in lymphoma tissues and normal lymph tissues was determined respectively. And the corre- lation of age, gender, immunophenotype, MYC gene and B cell lymphoma 6 protein （BCL-6） with miR were also analyzed. Results The miR-21, miR-155 and miR-210 in lymphoma tissues were higher than those in normal lymph tissues, the differences were statistically significant （P 〈 0.05）. The miR-21, miR-155, miR-210 of NK/T cell lymphoma, mucosa - associated lymphoma in immunological typing were higher than those of DLBCL, miR-21, miR-155, miR-210 of nor- mal arrangement in MYC gene were higher than those of gene rearrangement, miR-21, miR-155 of expression in BCL-6 protein were lower than those of non-expression, the differences were statistically significant （P 〈 0.05）. The miR-21 and miR-155 were associated with immunophenotyping, MYC gene and BCL-6 protein expression in lymphoma patients, miR-210 expression was associated with immune classification and MYC gene in patients with lymphoma （P 〈 0.05）. Conclusion The miR-21, miR-155 and miR-210 participates in the development and progression of lymphoma, the high expression of miR may influence the prognosis of patients with lymphoma. The expression of miR-21, miR-155 and miR-210 in clinic has certain guiding significance for the follow-up treatment and prognosis.
出处
《中国医药导报》
CAS
2017年第23期84-87,共4页
China Medical Herald
