摘要
目的观察人参多糖联合化疗治疗中晚期消化道肿瘤的临床疗效及安全性,研究其对患者免疫功能的影响。方法60例中晚期消化道肿瘤患者随机分为治疗组和对照组,每组30例,均采用XELOX化疗方案,治疗组在化疗前2天给予人参多糖注射液。评估2组化疗前及化疗2周期后近期疗效,记录体力状况(KPS评分)及体质量变化情况,记录化疗后毒副反应发生情况,流式细胞仪检测各组血中T淋巴细胞抗原(CD_3、CD_4、CD_8)、B淋巴细胞抗原(CD19、CD20)、自然杀伤细胞表面抗原(CD_(16)、CD_(56))。结果 2组近期疗效及毒副反应发生情况无显著差异(P>0.05);化疗后,2组KPS评分、体质量均较化疗前明显降低(P<0.01);治疗组KPS评分明显高于对照组(P<0.01);2组血CD_3、CD_4、CD_(16)、CD_(56)百分比均较化疗前明显升高,CD8百分比较化疗前明显降低(P<0.05或P<0.01);治疗组较对照组升高/降低的更加明显(P<0.01)。结论人参多糖可以在一定程度上提高患者免疫功能,并改善患者一般状况,临床应用安全有效。
Objective To observe the clinical efficacy and safety of ginseng polysaccharides combined with chemotherapy in patients with moderate and advanced gastrointestinal cancer, and to study its influence on patients＇immunological function. Methods A total of 60 patients with moder- ate and advanced gastrointestinal cancer were randomly divided into treatment group and control group, with 30 cases per group. Both groups received XELOX chemotherapeutic protocol, and treat- ment group was added with ginseng polysaccharides injection 2 d before chemotherapy. Short-term clinical efficacy before and 2 weeks after chemotherapy was evaluated, Karnofsky performance status （KPS） score and change of body weight as well as post-chemotherapeutic adverse and toxic reactions were recorded, and flow cytometry was used to detect the T lymphocyte antigens （ CD3, CD4 and CD8）, B lymphocyte antigens （CD19 and CD20） and natural killer cell surface antigens （CDl6 and CD56 ）. Results There was no significant difference between two groups in short-term clinical effica- cy and adverse and toxic reactions （P 〉 0.05 ）. After chemotherapy, KPS score and body weight de- creased evidently in both groups （P 〈0.01 ）, and KPS score was markedly higher in treatment group than that in control group （P 〈0.01 ）. The percentages of blood CD3 , CD4, CDl6 and CD56 increased notably whereas percentage of CDs decreased after chemotherapy than chemotherapy before （ P 〈 0. 0 5 or P 〈 0. 0 1 ） , which changed more significantly in treatment group than those in control group （ P 〈 O. 0 1 ）. Conclusion Ginseng polysaccharides can promote the immunological function and improve the general conditions of patients with moderate andadvanced gastrointestinal cancer to some extent, and is safe and effective in clinical application.
出处
《实用临床医药杂志》
CAS
2016年第23期36-39,共4页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11528634)
关键词
人参多糖
免疫功能
化疗
T淋巴细胞抗原
B淋巴细胞抗原
自然杀伤细胞表面抗原
ginseng polysaccharides
immunological function
chemotherapy
T lympho-cyte antigen
Blymphoeyte antigen
surface antigen of natural killer cells
