摘要
目的探讨调强放疗对头颈部肿瘤患者甲状腺功能的影响。方法 40例头颈部恶性肿瘤(不包括甲状腺来源的恶性肿瘤),接受调强适形放射治疗,采用放射免疫法检测放疗前及放疗后3、6、12、18及24个月的T3、T4以及TSH水平。结果 40例头颈部非甲状腺癌的恶性肿瘤患者中,放疗后3、6、12、18及24个月T3、T4下降及TSH升高分别有1例(2.5%)、3例(7.5%)、5例(12.5%)、7例(17.5%)和10例(25%),其中2例(5%)伴有轻度的表情淡漠等临床症状,给予补充甲状腺素治疗后好转。结论调强放射治疗可导致甲状腺功能不同程度的改变,且随着随访时间的延长,甲状腺功能损伤发生率呈增高趋势,应引起临床关注。
Objective To study the effect of intensity modulated radiotherapy on thyroid function in patients with head and neck cancer. Methods 40 cases of head and neck carcinoma （ excluding malignant tumors of the thyroid gland） received in- tensity modulated radiotherapy. T3 ,T4 and TSH levels were measured before radiotherapy and at 3,6,12,18 and 24 months after radiotherapy. Results There were 1 case（2.5%）,3 cases （7.5%）,5 cases （12.5%）,7 cases （17.5%） and 10 cases （25%） with thyroid hormone levels of T3/T4 lower and TSH higher than before in patients with head and neck non - thyroid cancer. 2 cases with mild clinical symptoms such as apathy while relieved after Thyroid hormone replacement. Conclusion Intensity modulated radiotherapy may lead to different degree of thyroid function injury. With the prolongation of follow-up time, the incidence of thyroid function injury increases,which should be paid more attention to.
出处
《实用癌症杂志》
2016年第12期2085-2086,共2页
The Practical Journal of Cancer
基金
九江市科技局基金项目(编号:20148666)
关键词
调强放疗
头颈部肿瘤
甲状腺损伤
Intensity modulated radiotherapy
Head and neck carcinoma
Thyroid injury
