摘要
目的 探讨参一胶囊在晚期非小细胞肺癌（NSCLC）维持治疗中的效果。方法 选取2013年7月~2015年10月收治的90例Ⅲb~Ⅳ期NSCLC患者为研究对象,按照随机数字表法分为对照组与研究组,每组各45例。对照组采取培美曲塞药物治疗,研究组采用参一胶囊维持治疗,两组均治疗4个周期。比较两组的总有效率、治疗受益率、KPS评分改善程度以及CD3＋、CD4＋、CD8＋及CD4＋/CD8＋等免疫功能指标;比较两组不良反应发生情况。结果 研究组总有效率为53.33%,治疗受益率为84.44%,均明显高于对照组的31.11%和66.67%,差异均有统计学意义（P〈0.05）。治疗后,研究组患者KPS评分总提高率明显高于对照组,两组的各项免疫功能指标均显著低于治疗前,且研究组高于对照组,差异均有统计学意义（P〈0.05）。两组治疗中均未出现严重不良反应。结论 晚期非小细胞肺癌患者采取参一胶囊维持治疗可以明显提高治疗效果、受益率及患者的生存质量,改善机体的免疫功能,值得临床推广应用。
Objective To invesigate the effect of Shenyi Capsules for advanced non-small cell lung cancer （NSCLC） maintenance treatment.Methods From July 2013 to October 2015,90 cases of advanced NSCLC patients with stage Ⅲb~Ⅳ were divided into control group and study group according to the random number table method,45 cases in each group.Control group was treated with pemetrexed,study group was treated with Shenyi Capsules.Patients of the two groups were treated for four cycles.The rate of total effective,rate of treatment benefit,KPS score,and immune function indexes such as CD3＋,CD4＋,CD8＋,CD4＋/CD8＋ of the two groups before and after treatment were compared;the adverse reactions of the two groups were compared.Results The total effective rate of the study group was 53.33%,and the rate of therapeutic benefit was 84.44%,which were significantly higher than those of the control group （31.11%,66.67%）,the differences were statistically significant （P〈0.05）.After treatment,the total increase rate of KPS score in the study group was significantly higher than that of the control group,and the immune function indexes of the two groups were signifi- cantly lower than those before treatment,and study group was higher than those of the control group,the differences were statistically significant （P〈 0.05）;there was no serious adverse reactions in two groups.Conclusion Shenyi Capsules maintenance treatment can significantly improve the efficiency,the quality of life and immune function of patients with advanced NSCLC,so it is worthy of clinical application.
出处
《中国当代医药》
2016年第33期85-87,97,共4页
China Modern Medicine
关键词
参一胶囊
晚期
非小细胞肺癌
维持治疗
效果
Shenyi capsules
Advanced
Non small cell lung cancer
Maintenance treatment
Effect
