摘要
目的观察中药鹤蟾片维持治疗中晚期非小细胞肺癌(NSCLC)的临床疗效和对无进展生存期的影响。方法选一线化疗后的中晚期非小细胞肺癌患者78例,随机分为治疗组44和对照组34例。治疗组给予鹤蟾片维持治疗,对照组随访观察。统计分析无进展生存期,并观察对生活质量的影响及身体的不良反应。结果入组78例,1例出组,77例可评价疗效,治疗前两组基线资料比较差异无统计学意义(P>0.05),治疗组和对照组中位无进展生存期分别为5.67月和4.12月,两者差异具有统计学意义(P=0.048)。两组患者生活质量改善比较差异亦有统计学意义(P<0.05)。结论中药鹤蟾片维持治疗中晚期NSCLC安全有效,可延长患者的无进展生存期,改善患者症状,且不良反应小。
Objective To evaluate the clinical efficacy and the progression-free survival（PFS） of maintenance therapy with Traditional Chinese Medicine Hechanpian in patients with intermidiate and advanced non-small cell lung cancer. Methods Seventy-eight cases of NSCLC in HI/IV stage after initial therapy 44 cases were randomly divided into treatment group and 34 cases control group. The 44 patients in the treatment group received Hechanpian and the other 34 patients in the control group received continual observation. Progression-free survival was used to analyze the quality of life and to observe the impact on each patient. Results There are 77 patients included in the trial and 1 patient excluded. Baseline charac- ters between groups has not achieved statistically difference （P^0.05）. Median PFS of the treatment group and control group are 5.67 month and 4. 12 month, respectively. The two groups have significant difference （ P = 0. {）48）, The quality of life between two groups also has statistically different （P 0.05）. Conclusion Maintenance treatment with Hechanpian is safe and feasible, it can prolong the PFS and improve symptom patients with intermidiate and advanced non-small cell lung cancer, and show a favorable toxicity profile.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2011年第10期1170-1172,共3页
Cancer Research on Prevention and Treatment
关键词
非小细胞肺癌
鹤蟾片
维持治疗
无进展生存期
Non-small cell lung cancer
Hechanpiam Maintenance treatment
Progression-free survival
