摘要
目的：分析儿童发生万古霉素不良反应（ADR）的一般特点及规律,为合理用药提供参考。方法：用Pareto最优分析,对2009-2015年湖南省儿童医院上报国家药品不良反应监测系统的38例万古霉素ADR报告进行整理,从患儿年龄、性别、用药后ADR发生时间、合并用药、ADR累及器官/系统及临床表现等方面进行统计分析。结果：发生万古霉素ADR的患儿中,男性高于女性（73.7%vs 26.3%）;患儿年龄集中在1个月-2岁（79.0%）;ADR发生时间主要在用药60 min以内（50.0%）和用药7 d后（21.1%）;有27例（71.1%）使用3种及以上药物联合治疗;ADR主要临床表现为过敏反应（64.6%）,主要累及皮肤及其附件。结论：临床医师、药师应了解儿童万古霉素ADR的特点和规律,加强其应用监测,以减少ADR的发生。
Objective： To study characteristics and rules of adverse drug reactions（ADR） induced by vancomycin,and provide references for clinical rational use of the drugs.Methods： The Pareto optimal analysis was adopted to analyze 38 cases of ADRs which were reported from Hunan Children＇s Hospital to the National Adverse Drug Reaction 2009 to 2015 in respect of the children＇s age,sex,time of occurrence of ADRs,combined medication,ADR involving organ systems and clinical manifestations.Results： ADRs induced by vancomycin in children,the proportion of boys was significantly higher than that of girls,1 mouth to 2 years old（79.0%）was the major age,most cases occurred in 60 minutes（50.0%） and 7 days（21.1%） after the drug use.Twenty-seven children（71.1%） were treated with three kinds of drugs or more.The clinical manifestations of ADR were allergic reaction（64.6%）.Conclusion： Clinical doctors and pharmacists should understand the pattern and characteristics of ADRs induced by vancomycin,and strengthen monitoring of its use to reduce occurrence of ADRs.
出处
《儿科药学杂志》
CAS
2016年第12期44-46,共3页
Journal of Pediatric Pharmacy
