摘要
目的：了解我院药品不良反应（ADR）发生的规律及特点,为临床合理用药提供参考。方法：采用Pareto最优分析,对2009–2014年上报的2395例ADR报告进行整理,对患者年龄、药物品种、抗菌药物品种、给药途径以及ADR临床表现进行分析和归纳。结果：2395例ADR中,51~60岁这个年龄段较易发生ADR（33.70%）,在所有药物中抗菌药物发生ADR的比例最大（26.01%）,其中头孢菌素发生例数最多（134例,21.51%）,发生ADR的主要给药途径为静脉滴注（66.72%）,ADR主要表现为皮肤及其附件损害（27.52%）。结论：依据ADR出现的特征与规律,合理掌握用药方式,并强化监护环节,运用有效的措施加以监测和管理,以降低ADR的发生。
Objective： To investigate the rules and the characteristics about adverse drug reactions happened in our hospital,and provide references for rational drug use in clinics. Methods： The Pareto optimal analysis was adopted to analyze the 2395 casesof ADR reports from 2009 to 2014, including patients＇ age, drug varieties, antibacterial varieties, routes of administration and clinicalmanifestations. Results： Among the 2395 ADRs, the patients＇ age at 51 – 60 were at risk of ADRs （33.70%）. Antibacterial drugs weremostly involved in 2395 ADR reports （26.01%）, in which, cephalosporins accounted for the highest （134 cases, 21.51%）. The mainroute of administration causing ADR was intravenous drip （66.72%）. The main clinical manifestations were the skin and its appendagesdamage （27.52%）. Conclusion： In order to reduce the incidence of ADR, the rational ways of administration should be mastered, theguardianship should be strengthened and effective measures should be taken to monitor and manage ADRs.
出处
《中国药物应用与监测》
CAS
2016年第2期101-104,共4页
Chinese Journal of Drug Application and Monitoring
