摘要
目的：探讨注射用核糖核酸Ⅱ所致不良反应（ ADR ）一般规律和特点。方法用Pareto最优分析对2010年10月至2014年1月我院使用注射用核糖核酸Ⅱ所致的39例ADR病例从患者年龄、给药途径、合并用药情况、用药后ADR发生时间及其临床表现等方面进行统计分析。结果39例ADR报告中，以40～59岁年龄段患者发生ADR最为普遍（66.7％）；全部为静脉滴注所致；有24例（61.6％）用3种及以上药物联合治疗；多数 ADR 发生在用药16 min 后（64.1％）。 ADR主要临床表现为累及皮肤及其附件损害（46.2％），其次为过敏样反应（38.4％）。结论临床医师、药师应了解核糖核酸Ⅱ不良反应的规律和特点，加强其应用监测，以减少不良反应的发生率。
Objective To investigate the general pattern and character-istics of adverse drug reaction （ ADR） induced by ribonucleic acid Ⅱ. Methods Pareto optimal analysis was adopted to analyze 39 cases of ADR induced by ribonucleic acid Ⅱoccurred in our hospital from Octo-ber 2010 to January 2014.Results Among 39 cases of ADR reports , the majority were people aged 40-59 years old （66.7%） , and all were caused by intravenous route of administration .24 patients （ 61.6%） were treated with more than three kinds of drugs .Most of cases occurred after 16 minutes （ 64.1%） .The clinical manifestations of ADR were mainly lesions of skin and its appendages （ 46.2%） , followed by ana-phylactoid reaction （38.4%） .Conclusion Clinical doctors and phar-macists should understand the pattern and characteristics of ADR induced by ribonucleic acid Ⅱ, and strengthen monitoring of its use in order to reduce occurrence of ADRs.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2015年第10期888-889,共2页
The Chinese Journal of Clinical Pharmacology
