摘要
目的:分析2型糖尿病(T2DM)患者分泌型卷曲相关蛋白5(SFRP5)水平和胰岛素抵抗(IR)与尿白蛋白的关系。方法:137例T2DM住院患者,根据尿白蛋白排泄率(UAER)分为三组:正常白蛋白尿组(DM1组,n=47);微量白蛋白尿组(DM2组,n=45);大量蛋白尿组(DM3组,n=45)。另选同期体检健康者作为对照组(NC组,n=50)。采用ELISE检测各组血清SFRP5、葡萄糖氧化酶法测定空腹血糖(FBG)、电化学发光免疫分析法测定空腹胰岛素(FINS),计算稳态胰岛素抵抗指数(HOMA-IR)。比较组间差异并分析其相关性。结果:与NC组比较,T2DM各组HOMA-IR、FINS、FBG和UAER均升高(P<0.05或P<0.01),以DM3组升高最明显(P<0.05或P<0.01);DM1组SFRP5水平显著低于NC组(P<0.01),但DM2组、DM3组则较DM1组升高,以DM3组升高最明显(P<0.01)。相关性分析显示,T2DM患者SFRP5与HOMA-IR呈正相关(r=0.507,P<0.01),且SFRP5和HOMA-IR与UAER亦成正相关(r=0.791、0.345,P<0.01)。结论:SFRP5可能与IR共同参与糖尿病肾病(DN)的发生发展,或可成为DN诊疗的新靶点。
Objective：To investigate the correlation of secreted frizzled-related protein 5（SFRP5）level and insulin resistance with albuminuria in type 2diabetes（T2DM）.Method：A total of 137 patients with T2 DM were enrolled.According to urinary albumin excretion rate,the patients with T2 DM were divided into three groups：normoalbuminurial group（DM1group,n=47）,microalbuminuria group（DM2group,n=45）,macroalbuminuria group（DM3group,n=45）.The control group included 50 healthy individuals（NC group）.Serum SFRP5 level was detected with ELISA method.Fasting blood glucose（FBG）was measured by gautose oxidase method.Fasting insulin（FINS）was measured by electrochemical iuminescence.Insulin resistance（HOMA-IR）was applied by homeostasis model assessment.To compare the differences of index among groups.Results：Compared with NC group,HOMA-IR,FINS,FBG and UAER in DM1 group,DM2group,DM3 group were increased,especially DM3 group was increased most obviously（P〈0.05 or P〈0.01）.SFRP5 in DM1group was significantly lower than NC group（P〈0.01）,but it in the DM2 group and DM3 group were higher than DM1 group,especially DM3 group was increased most obviously（P〈0.01）.Correlation analysis showed that SFRP5 level was positive correlated with HOMA-IR（r=0.507,P〈0.01）.SFRP5 and HOMA-IR,respectively,correlate with UAER（r=0.791,0.345,P〈0.01）.Conclusion：SFRP5and IR maybe involved in the occurrence and development of diabetic nephropathy（DN）,and may become the new target for diagnosis and treatment of DN.
出处
《微循环学杂志》
2016年第4期42-45,共4页
Chinese Journal of Microcirculation
关键词
分泌型卷曲相关蛋白5
胰岛素抵抗
2型糖尿病
糖尿病肾病
Secreted frizzled-related protein 5
Insulin resistance
Type 2diabetes mellitus
Diabetic nephropathy
