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胰岛素联合二甲双胍对妊娠期糖尿病的效果及妊娠结局分析 被引量:6

Analysis on insulin combined with metformin in treatment of gestational diabetes mellitus and its effects on pregnancy outcomes
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摘要 目的分析胰岛素联合二甲双胍在临床上治疗妊娠期糖尿病的效果,观察该治疗方法对妊娠结局的影响。方法抽取2018年1~12月于我院就诊的妊娠期糖尿病患者300例为研究对象,根据随机分配原则对其进行分组,分为观察组(n=150)与对照组(n=150),所有患者均严格控制饮食,积极锻炼,在其基础上,对照组患者采用胰岛素进行治疗,在对照组基础上,观察组患者加用二甲双胍治疗,比较两组患者的临床疗效与对妊娠结局的影响。结果观察组患者子痫前期与引产术率均低于对照组患者,差异有统计学意义(P <0.05);观察组患者蛋白尿与剖宫产发生率低于对照组患者,差异无统计学意义(P> 0.05);观察组患者空腹血糖控制率高于对照组患者,差异有统计学意义(P <0.05),观察组患者巨大儿、低血糖、黄疸儿、呼吸窘迫等不良结局优于对照组患者,差异有统计学意义(P <0.05)。结论临床上采用胰岛素联合二甲双胍治疗妊娠期糖尿病患者,可有效改善其妊娠结局,明显降低孕产妇并发症与围生儿并发症的发生,具有较高的临床应用价值。 Objective To analyze curative effects of insulin combined with metformin in treatment of gestational diabetes mellitus and to observe its effects on pregnancy outcomes. Methods 300 patients with gestational diabetes who were treated in our hospital from January to December 2018 were selected as research objects. According to the principle of random allocation, they were divided into observation group(n=150) and control group(n=150). All patients had strict diet control and active exercise. On the basis of this, the control group was treated with insulin. On the basis of the control group, the observation group was treated with metformin. The clinical curative effects and the effect on pregnancy outcomes of patients in the two groups were compared. Results The preeclampsia and induction rate in the observation group were lower than those in the control group, and the difference was statistically significant(P < 0.05). The incidence of proteinuria and cesarean section in the observation group was lower than that in the control group, and the difference was not statistically significant(P > 0.05). Fasting blood glucose control rate in the observation group was higher than that in the control group, and the difference was statistically significant(P < 0.05). The adverse outcomes of macrosomia, hypoglycemia, jaundice and respiratory distress in the observation group were better than those in the control group, with statistically significant differences(P < 0.05). Conclusion Insulin combined with metformin in clinical treatment of patients with gestational diabetes can effectively improve pregnancy outcomes and significantly reduce the incidence of maternal complications and perinatal complications, which has high clinical application values.
作者 陆叶 LU Ye(Medical Genetic Center,Jiangmen Maternal and Child Health Hospital,Guangdong,Jiangmen 529000,China)
出处 《中国医药科学》 2019年第23期77-79,共3页 China Medicine And Pharmacy
关键词 胰岛素 二甲双胍 妊娠期糖尿病 妊娠结局 Insulin Metformin Gestational diabetes mellitus Pregnancy outcomes
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